Anorexia nervosa viewed as an extreme weight condition: genetic implications

J Hebebrand, H Remschmidt - Human Genetics, 1995 - Springer
In anorexia nervosa, psychopathological features and reduced body weight are inseparable,
suggesting a prominent role of behavioral factors in achievement and maintenance of …

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

D Li, X Chang, JJ Connolly, L Tian, Y Liu, EJ Bhoj… - Scientific reports, 2017 - nature.com
We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a
stringently defined phenotype. Analysis of phenotypic variability led to the identification of a …

Genetics and epigenetics of eating disorders

Z Yilmaz, JA Hardaway, CM Bulik - Advances in genomics and …, 2015 - Taylor & Francis
Eating disorders (EDs) are serious psychiatric conditions influenced by biological,
psychological, and sociocultural factors. A better understanding of the genetics of these …

Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa

Z Yilmaz, JP Szatkiewicz, JJ Crowley… - Psychiatric …, 2017 - journals.lww.com
Anorexia nervosa (AN) is a serious and heritable psychiatric disorder. To date, studies of
copy number variants (CNVs) have been limited and inconclusive because of small sample …

A metabolic perspective on reward abnormalities in anorexia nervosa

P Duriez, N Ramoz, P Gorwood, O Viltart… - Trends in Endocrinology & …, 2019 - cell.com
Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate; however,
the mechanisms responsible for its pathogenesis remain largely unknown. Large-scale …

Eating disorders: the current status of molecular genetic research

S Scherag, J Hebebrand, A Hinney - European child & adolescent …, 2010 - Springer
Anorexia nervosa (AN) and bulimia nervosa (BN) are complex disorders characterized by
disordered eating behavior where the patient's attitude towards weight and shape, as well …

Anorexia nervosa: definition, epidemiology, and cycle of risk

CM Bulik, L Reba, AM Siega‐Riz… - … Journal of Eating …, 2005 - Wiley Online Library
Anorexia nervosa is a debilitating psychiatric disorder with profound biological,
psychological, and social consequences. After an initial evaluation of the most widely used …

One size does not fit all. Genomics differentiates among anorexia nervosa, bulimia nervosa, and binge‐eating disorder

C Hübel, M Abdulkadir, M Herle… - … Journal of Eating …, 2021 - Wiley Online Library
Objective Genome‐wide association studies have identified multiple genomic regions
associated with anorexia nervosa. No genome‐wide studies of other eating disorders, such …

Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers

K Nakabayashi, G Komaki, A Tajima, T Ando… - Journal of human …, 2009 - nature.com
Abstract The Japanese Genetic Research Group for Eating Disorders (JGRED) is a multisite
collaborative study group that was organized for the systematic recruitment of patients with …

Brain-based gene expression of putative risk genes for anorexia nervosa

SB Murray, J Rokicki, AM Sartorius, A Winterton… - Molecular …, 2023 - nature.com
The etiology of anorexia nervosa (AN) remains elusive. Recent genome-wide association
studies identified the first genes liked to AN which reached genome-wide significance …