Background: Medullary thyroid carcinoma (MTC) is a well-differentiated thyroid tumor that
maintains the typical features of C cells. An advanced stage and the presence of lymph node …

The frequency and prognostic relevance of RET proto-oncogene somatic mutations in
sporadic medullary thyroid carcinoma (MTC) remain controversial. In order to study somatic …

Background The RET proto-oncogene is responsible for the pathogenesis of hereditary
(98%) and sporadic (40%) medullary thyroid carcinoma (MTC). In sporadic MTC, somatic …

The hereditary multiple endocrine neoplasia syndromes types 2A and B (MEN 2A and B)
were recently linked to germline mutations in the RET proto-oncogene, altering one of five …

OBJECTIVE We have determined the frequency of specific mutations in the RET proto‐
oncogene in sporadic medullary thyroid carcinomas (MTCs) and correlated the presence or …

Objective Medullary thyroid carcinoma (MTC) derives from the parafollicular C cells, being
sporadic in 75% of cases and familial in 25%, due to RET proto-oncogene germinal …

Abstract Analysis of peripheral blood or tumor DNA samples from 101 patients with apparent
sporadic medullary thyroid carcinoma (MTC) was performed to assess the frequency of RET …

Background: Germline RET gene mutations are causative of multiple endocrine neoplasia
(MEN) 2 and may be identified by genetic screening. Three different syndromes are …

We have determined the frequency of 918 RET proto‐oncogene mutations (ATG→ ACG) in
primary MTC tumors and metastases and correlated the presence or absence of this …

Background: Pathogenic germline mutations affecting the RET proto-oncogene underlie the
development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were …