[Adaptation of reverse transcriptase polymerase chain reaction for clinical diagnosis of
expression of MDR1 gene]. - Abstract - Europe PMC Sign in | Create an account https://orcid.org …

Accurate quantification of multidrug resistance-1 gene (MDR1) expression in target cells
would be of important therapeutic value in predicting cellular response to anticancer drugs …

The multidrug resistance gene MDR1 (ABCB1) codes for a P-glycoprotein that acts as an
ATP-dependent transporter and is involved in removing drugs, xenobiotics, and peptides …

There exists a marked inter-individual variability of P-glycoprotein expression and activity,
which can be of clinical importance due to the large number of drugs that are substrates for …

We report an original application of competitive reverse transcription-polymerase chain
reaction (RT-PCR) for the quantification of MDR1 mRNA in clinical specimens by …

Abstract C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1)
gene have substantial impact on expression or activity of P‐glycoprotein (P‐gp). We …

The MDR1 gene encodes the glycoprotein P-170 which is mostly the molecular base of
multidrug resistance (MDR) providing a channel for an active efflux of cytostatics out of the …

Methods Blood samples from healthy individuals were collected in the Republican
Diagnostic Center, Astana, Kazakhstan. The research samples included 461 healthy people …

Tumor cell resistance to cytotoxic drugs is considered one of the major obstacles to
successful chemotherapy. Multidrug resistance (MDR) describes the simultaneous …

The results obtained from 12 laboratories, dealing with six identical malignant solid tumors,
assessing MDR1 phenotype using molecular techniques and immunohistochemistry have …