N-acetylglucosamine prevents IL-1β-mediated activation of human chondrocytes
AR Shikhman, K Kuhn, N Alaaeddine… - The Journal of …, 2001 - journals.aai.org
Glucosamine represents one of the most commonly used drugs to treat osteoarthritis.
However, mechanisms of its antiarthritic activities are still poorly understood. The present …
However, mechanisms of its antiarthritic activities are still poorly understood. The present …
Glucosamine modulates IL‐1‐induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF‐κB pathway
JN Gouze, A Bianchi, P Becuwe, M Dauca… - FEBS …, 2002 - Wiley Online Library
We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and
in UDP‐glucuronosyltransferase I mRNA expression induced by interleukin‐1β (IL …
in UDP‐glucuronosyltransferase I mRNA expression induced by interleukin‐1β (IL …
[HTML][HTML] Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes
R Largo, MA Alvarez-Soria, I Dıez-Ortego… - Osteoarthritis and …, 2003 - Elsevier
Objective: Glucosamine sulfate (GS) is a commonly used drug for the treatment of
osteoarthritis. The mechanism of the action of this drug does, however, remain to be …
osteoarthritis. The mechanism of the action of this drug does, however, remain to be …
[HTML][HTML] Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β
JN Gouze, E Gouze, MP Popp, ML Bush… - Arthritis research & …, 2006 - Springer
The effects of exogenous glucosamine on the biology of articular chondrocytes were
determined by examining global transcription patterns under normal culture conditions and …
determined by examining global transcription patterns under normal culture conditions and …
Recent aspects of the anti-inflammatory actions of glucosamine
I Nagaoka, M Igarashi, J Hua, Y Ju, S Yomogida… - Carbohydrate …, 2011 - Elsevier
Glucosamine, a naturally occurring amino monosaccharide, is present in the connective and
cartilage tissues as a component of glycosaminoglycans. Thus, glucosamine has been …
cartilage tissues as a component of glycosaminoglycans. Thus, glucosamine has been …
Glucosamine inhibits inducible nitric oxide synthesis
CJ Meininger, KA Kelly, H Li, TE Haynes… - … and biophysical research …, 2000 - Elsevier
Glucosamine is widely used in Europe for treatment of arthritis in humans. Based on recent
findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) …
findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) …
Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils
J Hua, K Sakamoto, I Nagaoka - Journal of leukocyte biology, 2002 - academic.oup.com
Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage
tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In …
tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In …
Evaluation of the suppressive actions of glucosamine on the interleukin-1β-mediated activation of synoviocytes
J Hua, K Sakamoto, T Kikukawa, C Abe… - Inflammation …, 2007 - Springer
Objective: Recently, we found that administration of glucosamine to adjuvant arthritis, a
model for rheumatoid arthritis, suppressed the progression of arthritis in rats. To clarify its …
model for rheumatoid arthritis, suppressed the progression of arthritis in rats. To clarify its …
[HTML][HTML] Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in …
OBJECTIVE: To study the effects of oral glucosamine sulfate on the development of
osteoarthritis (OA) and to examine concomitant changes in the nociceptive behavior of rats …
osteoarthritis (OA) and to examine concomitant changes in the nociceptive behavior of rats …
[HTML][HTML] Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine
N Ivanovska, P Dimitrova - Arthritis research & therapy, 2011 - Springer
Introduction Glucosamine is an amino-monosaccharide and precursor of
glycosaminoglycans, major components of joint cartilage. Glucosamine has been clinically …
glycosaminoglycans, major components of joint cartilage. Glucosamine has been clinically …