Rationale: Endothelial dysfunction is of interest in relation to smoking-associated
emphysema, a component of chronic obstructive pulmonary disease (COPD). We previously …

Recent evidence suggests that endothelial dysfunction and pathology of pulmonary vascular
responses may serve as a precursor to smoking-associated emphysema. Although it is …

Background Exposure to cigarette smoke has been shown to lead to vascular remodelling.
Computed tomography (CT) imaging measures of vascular pruning have been associated …

Rationale: Cigarette smoke exposure is a risk factor for many lung diseases, and histologic
studies suggest that tobacco-related vasoconstriction and vessel loss plays a role in the …

Rationale: Angiographic investigation suggests that pulmonary vascular remodeling in
smokers is characterized by distal pruning of the blood vessels. Objectives: Using volumetric …

Background Emphysema and small airway disease both contribute to chronic obstructive
pulmonary disease (COPD), a disease characterised by accelerated decline in lung …

Background The correlation between visual emphysema patterns and subsequent
progression of disease may provide a way to enrich a study population for treatment trials of …

Rationale: Emphysema occurs in distinct pathologic patterns, but little is known about the
epidemiologic associations of these patterns. Standard quantitative measures of …

Background Smoking cessation is of major importance for all smokers; however, in patients
with COPD, little information exists on how smoking cessation influences lung function and …

Emphysema distribution is associated with chronic obstructive pulmonary disease. It is,
however, unknown whether computed tomography (CT)-quantified emphysema distribution …