[HTML][HTML] Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index
Background The exposome is defined as encompassing all environmental exposures one
undergoes from conception onwards. Challenges of the application of this concept to …
undergoes from conception onwards. Challenges of the application of this concept to …
Epigenetics and the exposome: DNA methylation as a proxy for health impacts of prenatal environmental exposures
The accumulation of everyday exposures can impact health across the life course, but our
understanding of such exposures is impeded by our ability to delineate the relationship …
understanding of such exposures is impeded by our ability to delineate the relationship …
DNA methylation signatures as biomarkers of prior environmental exposures
C Ladd-Acosta, MD Fallin - Current epidemiology reports, 2019 - Springer
Abstract Purpose of Review This review demonstrates the growing body of evidence
connecting DNA methylation to prior exposure. It highlights the potential to use DNA …
connecting DNA methylation to prior exposure. It highlights the potential to use DNA …
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy
Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures
may play a critical role in early programming for childhood and adult illness. Maternal …
may play a critical role in early programming for childhood and adult illness. Maternal …
Linking prenatal environmental exposures to lifetime health with epigenome-wide association studies: state-of-the-science review and future recommendations
Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
DNA methylation–based biomarkers of environmental exposures for human population studies
JC Nwanaji-Enwerem, E Colicino - Current environmental health reports, 2020 - Springer
Abstract Purpose of Review This manuscript orients the reader to the underlying motivations
of environmental biomarker development for human population studies and provides the …
of environmental biomarker development for human population studies and provides the …
Early-life environmental exposures and childhood obesity: an exposome-wide approach
Background: Chemical and nonchemical environmental exposures are increasingly
suspected to influence the development of obesity, especially during early life, but studies …
suspected to influence the development of obesity, especially during early life, but studies …
Cohort profile: pregnancy and childhood epigenetics (PACE) consortium
JF Felix, BR Joubert, AA Baccarelli… - International journal …, 2018 - academic.oup.com
Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA
sequence, but can influence its function. Currently, DNA methylation is the most studied …
sequence, but can influence its function. Currently, DNA methylation is the most studied …
Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and disease …
Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …
environmental health researchers studying the environmental influences on human …
Machine learning-based DNA methylation score for fetal exposure to maternal smoking: development and validation in samples collected from adolescents and adults
S Rauschert, PE Melton, A Heiskala… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Fetal exposure to maternal smoking during pregnancy is associated with the
development of noncommunicable diseases in the offspring. Maternal smoking may induce …
development of noncommunicable diseases in the offspring. Maternal smoking may induce …