Sirtuins, aging, and metabolism
L Guarente - Cold Spring Harbor symposia on quantitative …, 2011 - symposium.cshlp.org
Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that
link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially …
link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially …
The sirtuin family's role in aging and age-associated pathologies
The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …
Sirtuins in neurodegenerative diseases: an update on potential mechanisms
SW Min, PD Sohn, SH Cho, RA Swanson… - Frontiers in aging …, 2013 - frontiersin.org
Silent i nformation r egulator 2 prote ins (sirt uin s or SIRTs) are a group of deacetylases (or
deacylases) whose activities are dependent on and regulated by nicotinamide adenine …
deacylases) whose activities are dependent on and regulated by nicotinamide adenine …
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease
JC Newman, W He, E Verdin - Journal of Biological Chemistry, 2012 - ASBMB
The sirtuins are a family of NAD+-dependent protein deacetylases that regulate cell survival,
metabolism, and longevity. Three sirtuins, SIRT3–5, localize to mitochondria. Expression of …
metabolism, and longevity. Three sirtuins, SIRT3–5, localize to mitochondria. Expression of …
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
A Giralt, F Villarroya - Biochemical Journal, 2012 - portlandpress.com
SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized
to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in …
to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in …
Cellular and molecular effects of sirtuins in health and disease
Y Horio, T Hayashi, A Kuno, R Kunimoto - Clinical science, 2011 - portlandpress.com
Sirtuins are NAD+-dependent protein deacetylases that are broadly conserved from bacteria
to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention …
to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention …
Sirtuins at a glance
T Nakagawa, L Guarente - Journal of cell science, 2011 - journals.biologists.com
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …
Mitochondrial sirtuins: regulators of protein acylation and metabolism
Sirtuins are NAD+-dependent protein deacetylases and have been implicated in the
regulation of metabolism, stress responses, and aging. Three sirtuins are located in …
regulation of metabolism, stress responses, and aging. Three sirtuins are located in …
[HTML][HTML] Sirtuin regulation in aging and injury
N Poulose, R Raju - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …
SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism
MD Hirschey, T Shimazu, JY Huang… - Cold Spring Harbor …, 2011 - symposium.cshlp.org
The sirtuins are a family of nicotinamide adenine dinucleotide (NAD+)-dependent protein
deacetylases that regulate cell survival, metabolism, and longevity. Humans have seven …
deacetylases that regulate cell survival, metabolism, and longevity. Humans have seven …