Vascularized composite allotransplantation (VCA) has emerged as a useful reconstructive
option for patients suffering from major tissue defects and functional deficits. While the …

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct
pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; …

The development of microsurgical techniques has facilitated the establishment of fully
vascularized cardiac transplantation models in small mammals. A particularly useful model …

CARDIAC allograft vasculopathy (CAV) is characterized by allograft vascular injury induced
by a variety of noxious stimuli, including the immune system response to the allograft …

Recent studies show that alloantibodies mediate a substantial proportion of graft-rejection
episodes, contributing to both early and late graft loss. Rejection that is caused by antibody …

OBJECTIVE: We sought to assess the importance of Th1 cells for the development of cardiac
allograft vasculopathy. BACKGROUND: Despite improvements in immunosuppressive …

Cardiac allograft vasculopathy remains a major challenge to long-term survival after heart
transplantation. Endothelial injury and dysfunction, as a result of multifactorial immunologic …

Current pharmacologic regimens in transplantation prevent allograft rejection through
systemic recipient immunosuppression but are associated with severe morbidity and …

We investigated the influence of allograft primary vascularization on alloimmunity, rejection,
and tolerance in mice. First, we showed that fully allogeneic primarily vascularized and …

The development of transplant arteriosclerosis (TA) is today's most important problem in
clinical organ transplantation. Histologically, TA is characterized by perivascular …