An improvement in outcomes after VCA transplantation has the potential to revolutionize the
field. Several effective therapeutic strategies have demonstrated great promise …

Transplant rejection represents a diverse series of complex immunological events beginning
with allorecognition and lymphocyte activation and differentiation, followed by interactions of …

Vascularized composite allografts (VCAs) of faces and extremities are subject to chronic
rejection that is incompletely understood. Here we report on immunoproteomic evaluation of …

Kidney transplantation entails a high likelihood of endothelial injury. The endothelium is a
target of choice for injury by ischemia-reperfusion, alloantibodies, and autoantibodies. A …

BACKGROUND: Chronic allograft vasculopathy (CAV) is caused by the infiltration of host
immune cells to a graft, but it has been technically difficult to monitor the movements of the …

Transplantation is the only curative treatment for patients with kidney failure but it poses
unique immunological challenges that must be overcome to prevent allograft rejection and …

Vascularized composite allograft (VCA) transplantation, or reconstructive transplantation,
has revolutionized the treatment of complex tissue and functional defects. Despite arriving …

Cardiac allograft vasculopathy (CAV) has a high prevalence among patients that have
undergone heart transplantation. Cardiac allograft vasculopathy is a multifactorial process in …

Graft endothelial cell (EC) injury is central to the pathogenesis of antibody-mediated
rejection (AMR). The ability of donor-specific antibodies (DSA) to bind C1q and activate the …

We herein summarize the progress made in VCA in the last year with a focus on new clinical
immunosuppressive strategies and novel targets for immunosuppression and …