Résumé Pour ce projet, nous avons développé une plateforme pour l'analyse
pangénomique de la méthylation de l'ADN chez le bovin qui est compatible avec des …

Background Oocytes and early embryos contain minute amounts of DNA, RNA and proteins,
making the study of early mammalian development highly challenging. The study of the …

Monozygotic (MZ) twins are of great interest to elucidate the contributions of pre-and
postnatal environmental factors on epigenetics in the expression of complex traits and …

Aim: There is a growing concern about the potential adverse effects of high dose folic acid
(FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl …

Background The timing of the first cell divisions may predict the developmental potential of
an embryo, including its ability to establish pregnancy. Besides differences related to …

Most often, in vitro produced embryos display poor quality and altered gene expression
patterns compared to their in vivo counterparts. Aberrant DNA methylation occurring during …

Materials and methods: Embryonic genomic DNA was isolated from bovine in vitro-derived
blastocysts. Two pooled blastocyst samples were generated (pool 1, n= 17 blastocysts; pool …

The current decline in dairy cattle fertility has resulted in significant financial losses for dairy
farmers. In the past, most efforts to improve dairy cattle fertility have been focused on either …

Early embryonic loss and altered gene expression in in vitro produced blastocysts are
believed to be partly caused by aberrant DNA methylation. However, specific embryonic …

DNA methylation undergoes drastic fluctuation during early mammalian embryogenesis.
The dynamics of global DNA methylation in bovine embryos, however, have mostly been …