Paclitaxel-induced cytotoxicity, cell cycle perturbation, and apoptosis were determined in a
human ovarian cancer cell line expressing wt p53 (A2780) and in a subclone (A2780/E6) …

Nine human ovarian cancer cell lines that express wild-type (wt) or mutated p53 were used
to evaluate the cytotoxicity induced by paclitaxel. The IC50 calculated in the five mutated …

We conducted this study to determine whether the sensitivity of ovarian cancer cells to
paclitaxel (PTX) relates to cells undergoing p53-dependent apoptosis. Human ovarian …

Human ovarian cancer cell lines with different p53 status were investigated for p53-
dependency of cell cycle arrest upon treatment with cytostatic drugs. For this purpose …

Abstract Paclitaxel (PTX), a microtubule-active agent, blocks cell proliferation by inhibiting
mitotic progression leading to mitotic and postmitotic arrest and cell death. Here we …

The effect of taxol (TX) and cisplatin (CDDP), singly or in association, was assessed on two
human ovarian cancer cell lines, one sensitive (A2780) and one resistant (A2780 cp8) to …

Purpose: The antitumor agent paclitaxel (Taxol®) has been shown to arrest cells in mitosis
through microtubule stabilization and to induce apoptosis. The tumor suppressor gene p53 …

The p53 tumor suppressor gene is critical in regulating cell proliferation following DNA
damage, and disruption of p53 protein function by mutation has been implicated as a factor …

It has been shown recently that expression of p21 is enhanced by paclitaxel. This cytotoxic
compound induces mitotic spindle damage resulting in blockade of the mitotic cell cycle …

Mutations of the tumor suppressor wild-type p53 gene have been implicated in the
development of resistance to anticancer drugs. We have examined the role of wild-type p53 …