Purpose To evaluate noninvasive and clinically translatable magnetic resonance (MR)
imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of …

Molecularly targeted therapies promise to transform the treatment of cancer patients,
including those with brain tumors. A deeper understanding of the biology of brain tumors has …

Background: Neuroblastoma is the most common extracranial solid tumor in children, and
treatment options for recurrent neuroblastoma are limited. Using molecular profiling to target …

In the United States, approximately 17,000 people per year are diagnosed with braintumors,
the leading cause of death from cancers in children ages 1-15 year (1, 2). Gliomasare the …

Gene therapy for malignant brain tumors Gene therapy for malignant brain tumors Abstract This
paper presents three studies assessing the efficacy of gene therapy approach in the treatment …

The overall median survival in glioblastoma multiforme (GBM) patients is less than one year
and fewer than 5% of patients survive more than 5 years. The current standard of care for …

Microarray technologies have come into prominence for the assessment of molecular
diagnostic profiles in cancer tissue biopsies. To better understand the effect of sampling …

Gliomas are the most common intracerebral tumors in adults and pose significant imaging
and treatment challenges due to their invasive nature, and wide variability in tumor biology …

Despite advances in neurosurgery, radiation, and chemotherapy, the prognosis of patients
with malignant brain tumors still remains grim. Considerable efforts have been made to …