Mechanistic evaluation of the glucose-induced reduction in initial burst release of octreotide acetate from poly (D, L-lactide-co-glycolide) microspheres

J Wang, BM Wang, SP Schwendeman - Biomaterials, 2004 - Elsevier
One major obstacle for development of injectable biodegradable microspheres for controlled
peptide and protein delivery is the high initial burst of drug release occurring over the first …

Tunable delayed controlled release profile from layered polymeric microparticles

D Dutta, C Fauer, K Hickey, M Salifu… - Journal of materials …, 2017 - pubs.rsc.org
Composite microparticles (MPs) with layered architecture, engineered from poly (L-lactic
acid)(PLLA) and poly (D, L-lactic-co-glycolic acid)(PLGA), are promising devices for …

Precision polymer microparticles for controlled-release drug delivery

C Berkland, K Kim, DW Pack - 2004 - ACS Publications
Fabrication of biodegradable polymer microparticles with precise size control provides a
means for enhanced control of drug delivery rates. The ability to control delivery kinetics is …

A biomimetic approach to active self-microencapsulation of proteins in PLGA

RB Shah, SP Schwendeman - Journal of Controlled Release, 2014 - Elsevier
A biomimetic approach to organic solvent-free microencapsulation of proteins based on the
self-healing capacity of poly (dl)-lactic-co-glycolic acid (PLGA) microspheres containing …

Biodegradable defined shaped printed polymer microcapsules for drug delivery

V Kudryavtseva, S Boi, J Read… - … Applied Materials & …, 2021 - ACS Publications
This work describes the preparation and characterization of printed biodegradable polymer
(polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules …

Microspheres Made of Poly(ε‐caprolactone)‐Based Amphiphilic Copolymers: Potential in Sustained Delivery of Proteins

F Quaglia, L Ostacolo, G Nese… - Macromolecular …, 2005 - Wiley Online Library
Microspheres of amphiphilic multi‐block poly (ester‐ether) s (PEE) s and poly (ester‐ether‐
amide) s (PEEA) s based on poly (ε‐caprolactone)(PCL) were investigated as delivery …

Facile preparation of PLGA microspheres with diverse internal structures by modified double‐emulsion method for controlled release

F Han, F Zhou, X Yang, J Zhao… - … Engineering & Science, 2015 - Wiley Online Library
Poly (l‐lactide‐co‐glycolide)(PLGA) microspheres with diverse internal structures and
different release behaviors were prepared via a modified double‐emulsion method by …

Issues in long-term protein delivery using biodegradable microparticles

M Ye, S Kim, K Park - Journal of Controlled Release, 2010 - Elsevier
Recently, a variety of bioactive protein drugs have been available in large quantities as a
result of advances in biotechnology. Such availability has prompted development of long …

A simple method for the preparation of monodisperse protein-loaded microspheres with high encapsulation efficiencies

X Cheng, R Liu, Y He - European Journal of Pharmaceutics and …, 2010 - Elsevier
A simple method for the preparation of monodisperse protein-loaded polymer microspheres
is presented in this paper. The method is based on the co-extrusion of an internal phase of …

Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies

TH Lee, J Wang, CH Wang - Journal of controlled release, 2002 - Elsevier
Composite double-walled microspheres with biodegradable poly (l-lactic acid)(PLLA) shells
and poly (d, l-lactic–co-glycolic acid)(PLGA) cores were fabricated with highly water-soluble …