Recent advances in intraoperative nerve bioimaging: fluorescence‐guided surgery for nerve preservation

Y Chen, H Zhang, Z Lei, F Zhang - Small Structures, 2020 - Wiley Online Library
Accidental transection or injury of nerves during surgeries leads to severe patient morbidity
and lowers the life quality of patients. The current imaging modality for nerves, such as …

Fluorescence imaging of nerves during surgery

EM Walsh, D Cole, KE Tipirneni, KI Bland… - Annals of …, 2019 - journals.lww.com
Objective: This review details the agents for fluorescence-guided nerve imaging in both
preclinical and clinical use to identify factors important in selecting nerve-specific fluorescent …

Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging

LG Wang, SL Gibbs - Current opinion in chemical biology, 2023 - Elsevier
Iatrogenic nerve injury represents one of the most feared surgical complications and
remains a major morbidity across many surgical specialties. Currently, no clinically …

Improved intraoperative visualization of nerves through a myelin-binding fluorophore and dual-mode laparoscopic imaging

VE Cotero, SY Kimm, TM Siclovan, R Zhang, EM Kim… - PloS one, 2015 - journals.plos.org
The ability to visualize and spare nerves during surgery is critical for avoiding chronic
morbidity, pain, and loss of function. Visualization of such critical anatomic structures is even …

[HTML][HTML] Nerve-targeted probes for fluorescence-guided intraoperative imaging

DV Hingorani, MA Whitney, B Friedman, JK Kwon… - Theranostics, 2018 - ncbi.nlm.nih.gov
A fundamental goal of many surgeries is nerve preservation, as inadvertent injury can lead
to patient morbidity including numbness, pain, localized paralysis and incontinence. Nerve …

Compact fluorescence and white-light imaging system for intraoperative visualization of nerves

D Gray, E Kim, V Cotero, P Staudinger… - … and Diagnostics VIII, 2012 - spiedigitallibrary.org
Fluorescence image guided surgery (FIGS) allows intraoperative visualization of critical
structures, with applications spanning neurology, cardiology and oncology. An unmet …

Nerve autofluorescence under near-ultraviolet light: cutting-edge technology for intra-operative neural tissue visualization in 17 patients

F Dip, D Rosenthal, M Socolovsky, J Falco… - Surgical …, 2022 - Springer
Background Nerve visualization and the identification of other neural tissues during surgery
is crucial for numerous reasons, including the prevention of iatrogenic nerve and neural …

[HTML][HTML] A clinically relevant formulation for direct administration of nerve specific fluorophores to mitigate iatrogenic nerve injury

CW Barth, VM Shah, LG Wang, AM Masillati… - Biomaterials, 2022 - Elsevier
Iatrogenic nerve injury significantly affects surgical outcomes. Although intraoperative
neuromonitoring is utilized, nerve identification remains challenging and the success of …

Intraoperative fluorescence imaging of peripheral and central nerves through a myelin-selective contrast agent

VE Cotero, T Siclovan, R Zhang, RL Carter… - Molecular Imaging and …, 2012 - Springer
Purpose Patients suffer from complications as a result of unintentional nerve damage during
surgery. We focus on improving intraoperative visualization of nerves through the use of a …

Dual-mode laparoscopic fluorescence image-guided surgery using a single camera

DC Gray, EM Kim, VE Cotero, A Bajaj… - Biomedical optics …, 2012 - opg.optica.org
Iatrogenic nerve damage is a leading cause of morbidity associated with many common
surgical procedures. Complications arising from these injuries may result in loss of function …