Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity

PY Huang, YY Zhu, H Zhong, PL Chen, QY Shi… - Biomaterials …, 2022 - pubs.rsc.org
The instinctive protective stress responses of tumor cells hamper low-temperature
photothermal therapy (LTPTT), resulting in tumor recurrence and metastasis. The rapid …

Autophagy inhibition enabled efficient photothermal therapy at a mild temperature

Z Zhou, Y Yan, K Hu, Y Zou, Y Li, R Ma, Q Zhang… - Biomaterials, 2017 - Elsevier
The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal
therapy commonly results in incomplete tumor eradication and serious damage of health …

Tumor acidity-responsive carrier-free nanodrugs based on targeting activation via ICG-templated assembly for NIR-II imaging-guided photothermal–chemotherapy

K Xue, F Wei, J Lin, H Tian, F Zhu, Y Li, Z Hou - Biomaterials Science, 2021 - pubs.rsc.org
Carrier-free nanodrugs composed of photosensitizers and chemotherapeutic drugs show
great potential in synergistic photothermal–chemotherapy. However, the targeting specificity …

Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging

X Shu, Y Chen, P Yan, Y Xiang, QY Shi, T Yin… - Journal of Controlled …, 2022 - Elsevier
Downregulation of adenosine triphosphate (ATP)-dependent heat shock proteins (HSPs)
can significantly reduce the tumorigenicity of cancer cells and overcome heat endurance to …

Native mitochondria-targeting polymeric nanoparticles for mild photothermal therapy rationally potentiated with immune checkpoints blockade to inhibit tumor …

Y Zhang, X He, Y Zhang, Y Zhao, S Lu, Y Peng… - Chemical Engineering …, 2021 - Elsevier
Photothermal therapy (PTT) is a promising therapeutic modality, but still faces some
potential limitations, such as unfavorable thermal damage to normal tissues, limited light …

A chloroquine-loaded Prussian blue platform with controllable autophagy inhibition for enhanced photothermal therapy

Y Ma, H Chen, B Hao, J Zhou, G He, Z Miao… - Journal of Materials …, 2018 - pubs.rsc.org
Insufficient and heterogeneously distributed heat commonly leads to the incomplete
elimination and recurrence of tumors. Inspired by the fact that autophagy is essential for cell …

A NIR-activated and mild-temperature-sensitive nanoplatform with an HSP90 inhibitor for combinatory chemotherapy and mild photothermal therapy in cancel cells

Y Peng, H Jiang, B Li, Y Liu, B Guo, W Gan - Pharmaceutics, 2023 - mdpi.com
Mild photothermal therapy (PTT) shows great potential to treat cancers while avoiding
unwanted damage to surrounding normal cells. However, the efficacy of mild PTT is …

Molecular targeting‐mediated mild‐temperature photothermal therapy with a smart albumin‐based nanodrug

G Gao, YW Jiang, W Sun, Y Guo, HR Jia, XW Yu… - Small, 2019 - Wiley Online Library
Photothermal therapy (PTT) usually requires hyperthermia> 50° C for effective tumor
ablation, which inevitably induces heating damage to the surrounding normal …

Light/pH-triggered biomimetic red blood cell membranes camouflaged small molecular drug assemblies for imaging-guided combinational chemo-photothermal …

S Ye, F Wang, Z Fan, Q Zhu, H Tian… - … applied materials & …, 2019 - ACS Publications
Nanoparticles camouflaged by red blood cell (RBC) membranes have attracted
considerable attention owing to reservation of structure of membrane and surface proteins …

Supramolecular photothermal nanomedicine mediated distant tumor inhibition via PD-1 and TIM-3 blockage

TY Huang, GL Huang, CY Zhang, BW Zhuang… - Frontiers in …, 2020 - frontiersin.org
Supramolecular nanoparticles for photothermal therapy (PTT) have shown promising
therapeutic efficacy in the primary tumor and great potential for turning the whole-body …