Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways
Y Meng, J Ji, X Xiao, M Li, S Niu, Y He… - Acta Biochimica …, 2021 - abp.ptbioch.edu.pl
As a kind of chronic inflammatory diseases, Rheumatoid arthritis (RA) has a low cure rate
and easy recurrence. It has widely reported that abnormal activation of mitogen-activated …
and easy recurrence. It has widely reported that abnormal activation of mitogen-activated …
Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through …
N Liu, X Feng, W Wang, X Zhao, X Li - Inflammation Research, 2017 - Springer
Background Fibroblast-like synoviocytes (FLS) play an essential role in the pathogenesis of
chronic inflammatory diseases, such as rheumatoid arthritis. Paeonol (Pae) is a phenolic …
chronic inflammatory diseases, such as rheumatoid arthritis. Paeonol (Pae) is a phenolic …
Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced by monocytes/
macrophage that plays a pathological role in rheumatoid arthritis (RA). In this study, we …
macrophage that plays a pathological role in rheumatoid arthritis (RA). In this study, we …
Oxymatrine prevents synovial inflammation and migration via blocking NF-κB activation in rheumatoid fibroblast-like synoviocytes
J Liang, B Chang, M Huang, W Huang, W Ma… - International …, 2018 - Elsevier
The fibroblast-like synoviocytes (FLSs) has the aggressive phenotype, which is very
important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the …
important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the …
Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway
J Tian, J Chen, J Gao, L Li, X Xie - Rheumatology international, 2013 - Springer
Abstract Resveratrol (trans-3, 4′-trihydroxystilbene), a natural phytoalexin, possesses anti-
inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for …
inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for …
Shikonin inhibits TNF-α production through suppressing PKC-NF-κB-dependent decrease of IL-10 in rheumatoid arthritis-like cell model
WX Sun, Y Liu, W Zhou, HW Li, J Yang… - Journal of natural …, 2017 - Springer
Shikonin, a major effective component in the Chinese herbal medicine Lithospermum
erythrorhizon Sieb., exhibits an anti-inflammatory property towards rheumatoid arthritis (RA) …
erythrorhizon Sieb., exhibits an anti-inflammatory property towards rheumatoid arthritis (RA) …
Effect of nobiletin on the MAPK/NF-κB signaling pathway in the synovial membrane of rats with arthritis induced by collagen
G Yang, S Li, L Yuan, Y Yang, MH Pan - Food & function, 2017 - pubs.rsc.org
Nobiletin (5, 6, 7, 8, 3′, 4′-hexamethoxyflavone) is a natural compound in the fruit peel of
citrus fruit in the Rutaceae family. It is active in inhibiting inflammation, reducing plasma …
citrus fruit in the Rutaceae family. It is active in inhibiting inflammation, reducing plasma …
Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1β-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by …
C Guo, L He, N Hu, X Zhao, L Gong, C Wang, C Peng… - Cytokine, 2022 - Elsevier
Background Fuzi lipid-soluble alkaloids (FLA) is the main bioactive components extracted
from the traditional Chinese medicine Aconiti Lateralis Radix Praeparata (“Fuzi” in Chinese) …
from the traditional Chinese medicine Aconiti Lateralis Radix Praeparata (“Fuzi” in Chinese) …
A novel function of artesunate on inhibiting migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
JD Ma, J Jing, JW Wang, T Yan, QH Li, YQ Mo… - Arthritis research & …, 2019 - Springer
Introduction Anti-malarial drug artesunate can suppress inflammation and prevent cartilage
and bone destruction in collagen-induced arthritis model in rats—suggesting it may be a …
and bone destruction in collagen-induced arthritis model in rats—suggesting it may be a …
The roles of synovial hyperplasia, angiogenesis and osteoclastogenesis in the protective effect of apigenin on collagen-induced arthritis
Y Li, B Yang, J Bai, S Xia, M Mao, X Li, N Li… - International …, 2019 - Elsevier
Apigenin (API) is a plant flavone that is known to exert a protective effect in rheumatoid
arthritis (RA), which is a chronic autoimmune disease. However, the molecular mechanism …
arthritis (RA), which is a chronic autoimmune disease. However, the molecular mechanism …