CD4+ CXCR5+ T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses
M Spaan, K Kreefft, GN de Graav, WP Brouwer… - Journal of …, 2015 - Elsevier
Background & Aims During chronic HCV infection, T cell dependent virus-specific antibodies
are produced. However, the role of BT cell interaction in chronic HCV is largely unknown …
are produced. However, the role of BT cell interaction in chronic HCV is largely unknown …
CD4+ CXCR5+ T cells activate CD27+ IgG+ B cells via IL-21 in patients with hepatitis C virus infection
FY Kong, B Feng, HH Zhang, HY Rao, JH Wang… - … & Pancreatic Diseases …, 2016 - Elsevier
Background Chronic hepatitis C virus (HCV) infection causes the skewing and activation of
B cell subsets, but the characteristics of IgG+ B cells in patients with chronic hepatitis C …
B cell subsets, but the characteristics of IgG+ B cells in patients with chronic hepatitis C …
[HTML][HTML] CXCL13-mediated recruitment of intrahepatic CXCR5+ CD8+ T cells favors viral control in chronic HBV infection
Y Li, L Tang, L Guo, C Chen, S Gu, Y Zhou, G Ye… - Journal of …, 2020 - Elsevier
Background & Aims Although CD8+ T cell exhaustion hampers viral control during chronic
HBV infection, the pool of CD8+ T cells is phenotypically and functionally heterogeneous …
HBV infection, the pool of CD8+ T cells is phenotypically and functionally heterogeneous …
Impaired function of CD4+ T follicular helper (Tfh) cells associated with hepatocellular carcinoma progression
Y Jia, Z Zeng, Y Li, Z Li, L Jin, Z Zhang, L Wang… - PloS one, 2015 - journals.plos.org
Background and Aims CD4+ T follicular helper (Tfh) cells, a new subset of immune cells,
have been demonstrated to be involved in the development and prognosis of tumors …
have been demonstrated to be involved in the development and prognosis of tumors …
HBV promotes the recruitment of IL‐17 secreting T cells via chemokines CCL22 and CCL17
K Zhang, Y Liu, X Yang, H Sun, X Shu… - Liver …, 2020 - Wiley Online Library
Abstract Background and Aims Little is known about the mechanisms of IL‐17 secreting T
cells accumulation in HBV‐transfected livers. Here, we investigated the role of the …
cells accumulation in HBV‐transfected livers. Here, we investigated the role of the …
HCV-specific interleukin-21+ CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C …
Abstract Interleukin-21 (IL-21)+ CD4+ T cells are involved in the immune response against
hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+ CD4+ T cells in the …
hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+ CD4+ T cells in the …
Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B
A Khanam, LSY Tang, S Kottilil - Hepatology, 2022 - Wiley Online Library
Abstract Background and Aims Classical CD8 T cells are implicated for protective and
pathogenic roles in chronic hepatitis B (CHB) infection. Recently, a subset of CD8 T cells …
pathogenic roles in chronic hepatitis B (CHB) infection. Recently, a subset of CD8 T cells …
Increased circulating follicular regulatory T-like cells may play a critical role in chronic hepatitis B virus infection and disease progression
X Wu, Z Su, B Cai, L Yan, Y Li, W Feng, L Wang - Viral immunology, 2018 - liebertpub.com
Follicular helper T cells (TFH) and follicular regulatory T cells (TFR), subsets of T cells, co-
regulate the reactions of germinal center (GC) B cells. TFH provide help to the GC response …
regulate the reactions of germinal center (GC) B cells. TFH provide help to the GC response …
Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection
RG Foster, L Golden-Mason, A Rutebemberwa… - Digestive diseases and …, 2012 - Springer
Abstract Background Effector CD4+ helper T cells have historically been classified into T
helper 1 (Th1) and Th2 based on the production of signature cytokines. The recently …
helper 1 (Th1) and Th2 based on the production of signature cytokines. The recently …
[HTML][HTML] Phenotype and function of CXCR5+ CD45RA− CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted …
Z Duan, J Gao, L Zhang, H Liang, X Huang, Q Xu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The present study reveals an immunological characterization of circulating and tumor-
infiltrating T follicular helper cells (Tfh), namely CXCR5+ CD45RA− CD4+ T cells, and their …
infiltrating T follicular helper cells (Tfh), namely CXCR5+ CD45RA− CD4+ T cells, and their …