Increased exonic de novo mutation rate in individuals with schizophrenia
Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral
and emotional processes. The wide spectrum of symptoms and clinical variability in …
and emotional processes. The wide spectrum of symptoms and clinical variability in …
Clinical genetics as clues to the “real” genetics of schizophrenia (a decade of modest gains while playing for time)
II Gottesman, P McGuffin, AE Farmer - Schizophrenia bulletin, 1987 - academic.oup.com
Although a decade has passed since the genetics of schizophrenia was examined for the
Schizophrenia Bulletin, the epigenetic puzzle of schizophrenia has not yielded its secrets to …
Schizophrenia Bulletin, the epigenetic puzzle of schizophrenia has not yielded its secrets to …
Recent advances in the genetics of schizophrenia
MC O'Donovan, NM Williams… - Human molecular …, 2003 - academic.oup.com
The high heritability of schizophrenia has stimulated much work aimed at identifying
susceptibility genes using positional genetics. As a result, several strong and well …
susceptibility genes using positional genetics. As a result, several strong and well …
[引用][C] Schizophrenia susceptibility and chromosome 6p24–22
SE Antonarakis, JL Blouin, AE Pulver, P Wolyniec… - Nature …, 1995 - nature.com
236 only')), assuming a narrow definition of the phenotype (DSM-III-R schizophrenia or
schizoaffective disorder). The most significant results were obtained for D6S296, using the …
schizoaffective disorder). The most significant results were obtained for D6S296, using the …
An international two–stage genome–wide search for schizophrenia susceptibility genes
HW Moises, L Yang, H Kristbjarnarson, C Wiese… - Nature …, 1995 - nature.com
Schizophrenia is thought to be a multifactorial disease with complex mode of inheritance1,
2. Using a two-stage strategy for another complex disorder, a number of putative IDDM …
2. Using a two-stage strategy for another complex disorder, a number of putative IDDM …
Molecular genetics of schizophrenia: a review of the recent literature
DF Levinson - Current Opinion in Psychiatry, 2003 - journals.lww.com
Schizophrenia linkage findings are beginning to converge on a number of chromosomal
regions. Linkage disequilibrium mapping studies are beginning to produce findings of great …
regions. Linkage disequilibrium mapping studies are beginning to produce findings of great …
[HTML][HTML] Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Indonesia Schizophrenia Consortium… - Nature, 2022 - research.vu.nl
Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
Puzzling over schizophrenia: schizophrenia as a pathway disease
PF Sullivan - Nature medicine, 2012 - nature.com
Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …
associated with cognitive impairment and finding the root of the disease remain priorities for …
Is there really a split in schizophrenia?: The genetic evidence
P McGuffin, AE Farmer, II Gottesman - The British Journal of …, 1987 - cambridge.org
Although the clinical presentation and course of schizophrenia is highly variable, it is
unclear whether this reflects heterogeneity at an aetiological level. The genetic evidence is …
unclear whether this reflects heterogeneity at an aetiological level. The genetic evidence is …