Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes
AE Pulver, J Mulle, G Nestadt, KL Swartz… - Molecular …, 2000 - nature.com
Despite considerable effort to identify susceptibility loci for schizophrenia, none have been
localized. Multiple genome scans and collaborative efforts have shown evidence for linkage …
localized. Multiple genome scans and collaborative efforts have shown evidence for linkage …
Genes for schizophrenia? Recent findings and their pathophysiological implications
PJ Harrison, MJ Owen - The Lancet, 2003 - thelancet.com
Context Schizophrenia is highly heritable, but the genes have remained elusive. Identifying
the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to …
the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to …
De novo mutation in schizophrenia
E Rees, G Kirov, MC O'Donovan… - Schizophrenia …, 2012 - academic.oup.com
Several studies in the last 5 years have shown that newly arising (de novo) mutations
contribute to the genetics of schizophrenia (SZ). This will replenish genetic variants removed …
contribute to the genetics of schizophrenia (SZ). This will replenish genetic variants removed …
The frustrating search for schizophrenia genes
MT Tsuang, SV Paraone - American Journal of Medical …, 2000 - Wiley Online Library
The articles in this issue of Seminars in Medical Genetics motivate two strong, but somewhat
paradoxical conclusions. A century of genetic epidemiologic research shows that genes play …
paradoxical conclusions. A century of genetic epidemiologic research shows that genes play …
Workshop on schizophrenia
SH Barondes, BM Alberts… - Proceedings of the …, 1997 - National Acad Sciences
On November 29–30, 1995, the National Academy of Sciences and the Institute of Medicine
brought together experts in schizophrenia and specialists in other areas of the biological …
brought together experts in schizophrenia and specialists in other areas of the biological …
An update on the genetics of schizophrenia
The ability of positional genetics to implicate novel genes and pathways will open up new
vistas for neurobiological research. Despite the accumulation of significant genetic data …
vistas for neurobiological research. Despite the accumulation of significant genetic data …
The genetics of schizophrenia
Behavioral genetic studies provide overwhelming evidence that genes contribute to
schizophrenia. Recently, genetic studies have provided promising evidence that …
schizophrenia. Recently, genetic studies have provided promising evidence that …
Will schizophrenia become a graveyard for molecular geneticists?
MJ Owen - Psychological medicine, 1992 - cambridge.org
We have little clear understanding of the structural or functional pathology of schizophrenia
despite many years of research. The only aetiological factor established beyond reasonable …
despite many years of research. The only aetiological factor established beyond reasonable …
The genetics of schizophrenia
A Bertolino, G Blasi - Neuroscience, 2009 - Elsevier
Research on the genetic factors conferring risk for schizophrenia has not provided definitive
answers. In the present review, we will discuss potential clinical and genetic limitations …
answers. In the present review, we will discuss potential clinical and genetic limitations …
[引用][C] The maddening hunt for madness genes
SO Moldin - Nature genetics, 1997 - nature.com
News of mapping disease loci that predispose to mental disorders engenders intense
interest, as scientists pinpoint exciting new directions for research and as affected …
interest, as scientists pinpoint exciting new directions for research and as affected …