Despite considerable effort to identify susceptibility loci for schizophrenia, none have been
localized. Multiple genome scans and collaborative efforts have shown evidence for linkage …

Context Schizophrenia is highly heritable, but the genes have remained elusive. Identifying
the genes is essential if the pathogenesis and pathophysiology of schizophrenia is finally to …

Several studies in the last 5 years have shown that newly arising (de novo) mutations
contribute to the genetics of schizophrenia (SZ). This will replenish genetic variants removed …

The articles in this issue of Seminars in Medical Genetics motivate two strong, but somewhat
paradoxical conclusions. A century of genetic epidemiologic research shows that genes play …

On November 29–30, 1995, the National Academy of Sciences and the Institute of Medicine
brought together experts in schizophrenia and specialists in other areas of the biological …

The ability of positional genetics to implicate novel genes and pathways will open up new
vistas for neurobiological research. Despite the accumulation of significant genetic data …

Behavioral genetic studies provide overwhelming evidence that genes contribute to
schizophrenia. Recently, genetic studies have provided promising evidence that …

We have little clear understanding of the structural or functional pathology of schizophrenia
despite many years of research. The only aetiological factor established beyond reasonable …

Research on the genetic factors conferring risk for schizophrenia has not provided definitive
answers. In the present review, we will discuss potential clinical and genetic limitations …

News of mapping disease loci that predispose to mental disorders engenders intense
interest, as scientists pinpoint exciting new directions for research and as affected …