Because the alpha-subunit of the rat lung epithelial Na channel (rENaC) is not expressed
until late fetal gestation, the developmental immaturity of alpha-rENaC may be involved in …

In the fetus, there is a net secretion of liquid (LL) by the lung as a result of active transport of
chloride ions. The rate of secretion and the resulting volume of LL are vital for normal lung …

Background: The aim of the present study was to investigate the expression and activity of
epithelial sodium channel (ENaC) in hyperoxia‐induced bronchopulmonary dysplasia …

In cultured alveolar epithelial cells, hypoxia induces a downregulation of the two main Na
proteins, the epithelial Na channel (ENaC) and the Na, K-ATPase. However, the in vivo …

Objective: Ambient hypoxia impairs the airway epithelial Na+ transport, which is crucial in
lung edema reabsorption. Whether chronic systemic hypoxemia affects airway Na+ transport …

Abstract Background Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome
(RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was …

Intra-amniotic exposure to proinflammatory cytokines such as interleukin-1 (IL-1) correlates
with a decreased incidence of respiratory distress syndrome (RDS) in infants following …

Active Na+ transport mediated by epithelial Na+ channel (ENaC) is vital for fetal lung fluid
reabsorption at birth and pulmonary edema resolution. Previously, we demonstrated that …

In utero, fetal lung epithelial cells actively secrete chloride (Cl−) ions into the lung airspaces.
Cl− ions enter the basolateral membranes through Na+/K+/2Cl−(NKCC) transporters (1) …

Knowledge about the conversion of the epithelium in the distal air spaces of the lung from
secretion to absorption is imperative to the understanding of postnatal lung development; …