Background Accumulating evidences suggest that sex affects lung development. Indeed, a
higher incidence of respiratory distress syndrome is observed in male compared to female …

UNLIKE OTHER EPITHELIAL TISSUES that transport large amounts of solutes and water,
the alveolar epithelium is faced with a unique physiological challenge. To facilitate optimal …

CONSIDERABLE PROGRESS HAS BEEN MADE in the past 20 years regarding our
understanding of pulmonary edema resolution. It is now relatively well accepted that this …

The fluid that fills the alveolar spaces in the fetal lung is cleared shortly after birth, mainly as
a consequence of active transport of sodium ions (Na+) across the alveolar epithelium. This …

Transition of the epithelium of the fetal lung from fluid secretion to fluid reabsorption requires
changes in the expression of ion channels. Corticosteroids regulate expression of several of …

In order for gas exchange to occur optimally, the alveoli must remain open and free from
fluid. In utero, the fetal lung is filled with fluid which is removed shortly after birth, mainly …

To explore interactions between the epithelial Na channel (ENaC) and neural precursor
expressed, developmentally downregulated protein 4-2 (Nedd4-2) at the conversion of the …

We tested the hypothesis that labor-induced epinephrine release would stimulate alveolar
fluid clearance in preterm fetuses. Preterm fetuses were obtained by cesarean section from …

Edema fluid (EF) increases epithelial Na+ transport by rat fetal distal lung epithelia (FDLE)
and induces net lung fluid absorption in fetal mouse lung explants [Rafii B, Gillie DJ …

Late in gestation, the developing air space epithelium switches from chloride and fluid
secretion to sodium and fluid absorption. Absorption requires Na-K-ATPase acting in …