Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …

A genuine and functional lymphatic vascular system is found in the meninges that sheath the
central nervous system (CNS). This unexpected (re) discovery led to a reevaluation of CNS …

The many interactions between the nervous and the immune systems, which are active in
both physiological and pathological states, have recently become more clearly delineated …

Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

There are no conventional lymphatic vessels within the CNS parenchyma, although it has
been hypothesized that lymphatics near the cribriform plate or dura maintain fluid …

Recent studies have shown that meningeal lymphatic vessels (MLVs), which are located
both dorsally and basally beneath the skull, provide a route for draining macromolecules …

Meningeal lymphatics near the cribriform plate undergo lymphangiogenesis during
neuroinflammation to drain excess fluid. Here, we hypothesized that lymphangiogenic …

Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …

At steady state, the CNS parenchyma has few to no lymphocytes and less potent Ag-
presentation capability compared with other organs. However, the meninges surrounding …

Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …