Background Fully understanding the developmental process of hepatic stem cells (HSCs)
and the mechanisms of their committed differentiation is essential for optimizing the …

Abstract Background: Delta‐like 1 (DLK1), a fetal liver stem cell marker, is strongly
expressed in human and rodent fetal liver, but not in adult liver. Notably, dysregulation of …

Cancer stem cells (CSCs) are responsible for tumor initiation and progression. We
previously showed that Delta-like homolog 1 (DLK1) may be a therapeutic target against the …

Abstract Delta-like 1 homolog (DLK1; Drosophila) is a hepatic stem/progenitor cell marker in
fetal livers that plays a vital role in oncogenesis of hepatocellular carcinoma (HCC). The aim …

Advances in stem cell biology have clarified that a tumour is a collection of heterogeneous
cell populations, and that only a small fraction of tumour cells possesses the potential to self …

Background & Aims: Previously, we showed high-level, long-term liver replacement after
transplantation of unfractionated embryonic day (ED) 14 fetal liver stem/progenitor cells …

Understanding the fetal hepatic niche is essential for optimizing the generation of functional
hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we …

Chronic liver injury is a risk factor for cirrhosis and hepatocellular carcinoma (HCC). The
molecular mechanisms that regulate the decision between normal injury repair and …

Hepatic stellate cells (HSCs) undergo myofibroblastic activation in liver fibrosis and
regeneration. This phenotypic switch is mechanistically similar to dedifferentiation of …

Chronic liver injury always progresses to fibrosis and eventually to cirrhosis, a massive
health care burden worldwide. Delta-like 1 (Dlk1) is well known as an inhibitor of adipocyte …