Distinct roles of Dlk1 isoforms in bi-potential differentiation of hepatic stem cells
J Huang, X Zhao, J Wang, Y Cheng, Q Wu… - Stem Cell Research & …, 2019 - Springer
Background Fully understanding the developmental process of hepatic stem cells (HSCs)
and the mechanisms of their committed differentiation is essential for optimizing the …
and the mechanisms of their committed differentiation is essential for optimizing the …
Delta‐like 1 contributes to cell growth by increasing the interferon‐inducible protein 16 expression in hepatocellular carcinoma
F Yu, X Hao, H Zhao, C Ge, M Yao, S Yang… - Liver …, 2010 - Wiley Online Library
Abstract Background: Delta‐like 1 (DLK1), a fetal liver stem cell marker, is strongly
expressed in human and rodent fetal liver, but not in adult liver. Notably, dysregulation of …
expressed in human and rodent fetal liver, but not in adult liver. Notably, dysregulation of …
[HTML][HTML] Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation
CM Cai, X Xiao, BH Wu, BF Wei, ZG Han - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) are responsible for tumor initiation and progression. We
previously showed that Delta-like homolog 1 (DLK1) may be a therapeutic target against the …
previously showed that Delta-like homolog 1 (DLK1) may be a therapeutic target against the …
DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma
Abstract Delta-like 1 homolog (DLK1; Drosophila) is a hepatic stem/progenitor cell marker in
fetal livers that plays a vital role in oncogenesis of hepatocellular carcinoma (HCC). The aim …
fetal livers that plays a vital role in oncogenesis of hepatocellular carcinoma (HCC). The aim …
hDlk-1: a cell surface marker common to normal hepatic stem/progenitor cells and carcinomas
H Nishina - The journal of biochemistry, 2012 - academic.oup.com
Advances in stem cell biology have clarified that a tumour is a collection of heterogeneous
cell populations, and that only a small fraction of tumour cells possesses the potential to self …
cell populations, and that only a small fraction of tumour cells possesses the potential to self …
Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver
M Oertel, A Menthena, YQ Chen, B Teisner, CH Jensen… - Gastroenterology, 2008 - Elsevier
Background & Aims: Previously, we showed high-level, long-term liver replacement after
transplantation of unfractionated embryonic day (ED) 14 fetal liver stem/progenitor cells …
transplantation of unfractionated embryonic day (ED) 14 fetal liver stem/progenitor cells …
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development
O Goldman, S Han, M Sourrisseau, N Dziedzic… - Cell stem cell, 2013 - cell.com
Understanding the fetal hepatic niche is essential for optimizing the generation of functional
hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we …
hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we …
Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism
N Ali, CB Nguyen, P Chandrakesan, RF Wolf, D Qu… - Scientific Reports, 2020 - nature.com
Chronic liver injury is a risk factor for cirrhosis and hepatocellular carcinoma (HCC). The
molecular mechanisms that regulate the decision between normal injury repair and …
molecular mechanisms that regulate the decision between normal injury repair and …
Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration
NL Zhu, K Asahina, J Wang, A Ueno, R Lazaro… - Journal of Biological …, 2012 - ASBMB
Hepatic stellate cells (HSCs) undergo myofibroblastic activation in liver fibrosis and
regeneration. This phenotypic switch is mechanistically similar to dedifferentiation of …
regeneration. This phenotypic switch is mechanistically similar to dedifferentiation of …
Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation
RL Pan, P Wang, LX Xiang, JZ Shao - Journal of Biological Chemistry, 2011 - ASBMB
Chronic liver injury always progresses to fibrosis and eventually to cirrhosis, a massive
health care burden worldwide. Delta-like 1 (Dlk1) is well known as an inhibitor of adipocyte …
health care burden worldwide. Delta-like 1 (Dlk1) is well known as an inhibitor of adipocyte …