Abstract Purpose of Review Sensory nerves (SNs) richly innervate bone and are a
component of bone microenvironment. Cancer metastasis in bone, which is under the …

Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is
associated with various complications, of which bone pain is most common and debilitating …

Introduction Cancer-induced bone pain (CIBP) is one of the most common and debilitating
complications associated with bone metastasis. Although our understanding of the precise …

Many common cancers such as breast, prostate, and lung cancer metastasize to bones at
advanced stages, producing severe pain and functional impairment. At present, the current …

Bone pain is one of the most common complications in cancer patients with bone
metastases. Although the mechanism of cancer-associated bone pain is poorly understood …

Simple Summary Cancer-induced bone pain severely impairs the quality of life of cancer
patients, many of whom suffer from inadequate pain relief. The development of new …

Cancerous cells can originate in a number of different tissues such as prostate, breast and
lung, but often go undetected and are non-painful. Many types of cancers have a propensity …

Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-
related complications. Bone pain is one of the most common complications associated with …

Cancers showing excessive innervation of sensory neurons (SN) in their microenvironments
are associated with poor outcomes due to promoted growth, increased tumor recurrence …

Bone cancer pain is a complex condition characterized by persistent, sudden, spontaneous
pain accompanied by hyperalgesia that typically arises from bone metastases or primary …