Autophagy is a crucial process for cells to maintain homeostasis and survival through
degradation of cellular proteins and organelles, including mitochondria and endoplasmic …

Mitophagy is a selective mode of autophagy in which mitochondria are specifically targeted
for degradation at the autophagolysosome. Mitophagy is activated by stresses such as …

Cancer is the leading cause of human deaths worldwide. Understanding the biology
underlying the evolution of cancer is important for reducing the economic and social burden …

Purpose: Hepatocellular carcinoma (HCC) ranks second in cancer mortality and has limited
therapeutic options. We recently described the synergistic effect of allosteric and ATP-site …

Cancer cells are characterized by malignant proliferation and aberrant metabolism and are
thereby liable to the depletion of nutrients and accumulation of metabolic waste. To maintain …

Purpose: Chemotherapy treatment of metastatic colon cancer ultimately fails due to
development of drug resistance. Identification of chemotherapy-induced changes in tumor …

Mitochondria play essential roles in cellular metabolism, redox homeostasis, and regulation
of cell death. Emerging evidences suggest that cancer cells exhibit various degrees of …

Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Mitochondrial activity and metabolic reprogramming influence the phenotype of cancer cells
and resistance to targeted therapy. We previously established that an insulin-like growth …

Significance: Mitochondria undergo constant morphological changes through fusion, fission,
and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous …