Background Mitochondrial homeostasis has been increasingly viewed as a potential target
of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function …

In the present study, we report that compound C, an inhibitor of a key intracellular energy
sensor AMP-activated protein kinase (AMPK), can induce autophagy in cancer cells. The …

Metformin is a well-established diabetes drug that prevents the onset of most types of human
cancers in diabetic patients, especially by targeting cancer stem cells. Metformin exerts its …

Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …

Onconase®(ONC) is a member of the RNase super-family that is secreted in oocytes and
early embryos of Rana pipiens. Over the last years, research interest about this small and …

Colorectal cancer (CRC) is the third most diagnosed cancer and the second most deadly
type of cancer worldwide. In late diagnosis, CRC can resist therapy regimens in which …

Epithelial malignancies are effectively treated by antiangiogenics; however, acquired
resistance is a major problem in cancer therapeutics. Epithelial tumors commonly have …

Mitophagy can selectively remove damaged mitochondria, which is critical in regulating
mitochondrial homeostasis in diseases, such as cancer. Herein, we found that Aloe gel …

The contribution that mitochondrial bioenergetics could have in cancer development is
debated. Here, we have generated HCT116-derived colocarcinoma cell lines expressing …

The transformation of normal cells to the cancerous stage involves multiple genetic changes
or mutations leading to hyperproliferation, resistance to apoptosis, and evasion of the host …