Human effective intestinal membrane permeability (Peff) is one of the two important
indicators for drug classification according to the Biopharmaceutical Classification System …

Absorption of drugs is the first step after dosing, and it largely affects drug bioavailability.
Hence, estimating the fraction of absorption (Fa) in humans is important in the early stages …

Solubility and permeability are recognized as key parameters governing drug intestinal
absorption and represent the basis for biopharmaceutics drug classification. The …

The biopharmaceutics classification system (BCS) and biopharmaceutics drug distribution
classification system (BDDCS) are complementary classification systems that can improve …

The main objective of this work was to investigate in-silico predictions of physicochemical
properties, in order to guide oral drug development by provisional biopharmaceutics …

Today, early characterization of drug properties by the Biopharmaceutics Classification
System (BCS) has attracted significant attention in pharmaceutical discovery and …

Intestinal absorption in human is routinely predicted in drug discovery using in vitro assays
such as permeability in the Madin-Darby canine kidney cell line. In silico models trained on …

Among the absorption, distribution, metabolism, elimination, and toxicity properties
(ADMET), unfavorable oral bioavailability is indeed an important reason for stopping further …

The accuracy of the provisional estimation of the Biopharmaceutics Classification System
(BCS) is heavily influenced by the permeability measurement. In this study, several …

The purpose of the present study was to investigate the effect of the physiological and
morphological differences between in vivo and in vitro systems on the estimation of in vivo …