A new biomarker for metastatic melanoma based on femtosecond pump-probe microscopy and supervised learning

D Grass, AM Selim, GM Beasley… - … in Dermatology and …, 2024 - spiedigitallibrary.org
Melanoma is responsible for around 10,000 deaths annually in the US. While simple
excision can cure most melanomas, some progress into metastatic cancer, necessitating …

Identifying metastatic melanoma with pump-probe microscopy of melanin

D Grass - Advanced Chemical Microscopy for Life Science …, 2024 - spiedigitallibrary.org
More patients diagnosed with stage I (local) melanoma die than any other metastatic stage,
because there exists no biomarker to reliably diagnose metastatic melanoma, preventing …

Pump-probe imaging of pigmented cutaneous melanoma primary lesions gives insight into metastatic potential

FE Robles, S Deb, JW Wilson, CS Gainey… - Biomedical optics …, 2015 - opg.optica.org
Metastatic melanoma is associated with a poor prognosis, but no method reliably predicts
which melanomas of a given stage will ultimately metastasize and which will not. While …

[HTML][HTML] Promising and Minimally Invasive Biomarkers: Targeting Melanoma

P Spiliopoulou, CD Holanda Lopes, A Spreafico - Cells, 2023 - mdpi.com
The therapeutic landscape of malignant melanoma has been radically reformed in recent
years, with novel treatments emerging in both the field of cancer immunotherapy and …

[HTML][HTML] Label-Free Delineation of Human Uveal Melanoma Infiltration With Pump–Probe Microscopy

B Zhang, T Yao, Y Chen, C Wang, Y Bao… - Frontiers in …, 2022 - frontiersin.org
Uveal melanoma (UM) is the most frequent primary intraocular malignancy in adults,
characterized by melanin depositions in melanocytes located in the uveal tract in the eyes …

Pump-probe imaging differentiates melanoma from melanocytic nevi

TE Matthews, IR Piletic, MA Selim… - Science translational …, 2011 - science.org
Melanoma diagnosis is clinically challenging: the accuracy of visual inspection by
dermatologists is highly variable and heavily weighted toward false positives. Even the …

Perspective: Melanoma diagnosis and monitoring: Sunrise for melanoma therapy but early detection remains in the shade

R Spanjaard, D Weaver, S Erramilli… - arXiv preprint arXiv …, 2015 - arxiv.org
Melanoma is one of the most dangerous forms of cancer. The five-year survival rate is 98% if
it is detected early. However, this rate plummets to 63% for regional disease and 17% when …

Pump-probe imaging illuminates molecular changes in metastatic melanoma (Conference Presentation)

WS Warren - … Microscopy in the Biomedical Sciences XIX, 2019 - spiedigitallibrary.org
More people die from melanoma after a Stage I diagnosis than after a Stage IV diagnosis,
because the tools available to clinicians do not readily identify which early-stage cancers …

Application of sequencing, liquid biopsies, and patient-derived xenografts for personalized medicine in melanoma

MR Girotti, G Gremel, R Lee, E Galvani, D Rothwell… - Cancer discovery, 2016 - AACR
Targeted therapies and immunotherapies have transformed melanoma care, extending
median survival from∼ 9 to over 25 months, but nevertheless most patients still die of their …

Prediction of melanoma metastasis using dermatoscopy deep features: An international multicenter cohort study.

K Lallas, P Spyridonos, H Kittler, P Tschandl… - 2024 - ascopubs.org
9565 Background: Machine learning algorithms, and especially convolutional neural
networks, demonstrated modest accuracy on the prediction of melanoma metastasis, based …