Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Interleukin-6 (IL-6) is a multifunctional cytokine which acts on a widevariety of cells,
regulating immune response, acute phase reaction and hematopoiesis. In accordance with …

▪ Abstract This essay summarizes my 40 years of research in immunology. As a young
physician, I encountered a patient with Waldenström's macroglobulinemia, and this inspired …

Abstract Interleukin (IL)-6 is a pleiotropic cytokine that has important roles in the regulation of
the immune response, inflammation, and hematopoiesis. Disruption of IL-6 regulation might …

Highlights•IL-6 promotes development of Th17 and Tfh cells and suppresses induction of
Treg.•IL-6 signals via three distinct mechanisms: classical, trans signaling and cluster …

Abstract Interleukin‐6 (IL‐6) is a multifunctional cytokine that plays a central role in host
defense due to its wide range of immune and hematopoietic activities and its potent ability to …

Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

The pleiotropic physiological functions of interleukin (IL-) 6 type cytokines range from
embryonic development and tissue homoeostasis to neuronal development and T cell …

The IL-10 cytokine family has nine members, four of which are located in the IL10 cluster on
chromosome 1q32. These cytokines are the immune regulatory cytokine IL-10 itself, and the …

Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now
known to be a multifunctional cytokine that regulates the immune response, hematopoiesis …