Rheumatoid arthritis: regulation of synovial inflammation

SE Sweeney, GS Firestein - The international journal of biochemistry & cell …, 2004 - Elsevier
Rheumatoid arthritis (RA) is a systemic, inflammatory autoimmune disorder that presents as
a symmetric polyarthritis associated with swelling and pain in multiple joints, often initially …

Developments in the scientific understanding of rheumatoid arthritis

JJ Goronzy, CM Weyand - Arthritis research & therapy, 2009 - Springer
Rheumatoid arthritis (RA) is recognized to be an autoimmune disease that causes
preclinical systemic abnormalities and eventually leads to synovial inflammation and …

Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis

U Müller-Ladner, T Pap, RE Gay, M Neidhart… - Nature clinical practice …, 2005 - nature.com
Rheumatoid arthritis is a complex systemic disease that ultimately leads to the progressive
destruction of articular and periarticular structures. Novel data indicate that the innate …

Molecular targets of rheumatoid arthritis

H Okamoto, D Hoshi, A Kiire… - … & Allergy-Drug …, 2008 - ingentaconnect.com
Rheumatoid arthritis (RA) is a multifactorial disease characterized by chronic inflammation of
the joints. Both genetic and environmental factors are involved in the pathogenesis of joint …

Rheumatoid arthritis: pathogenic roles of diverse immune cells

S Jang, EJ Kwon, JJ Lee - International journal of molecular sciences, 2022 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

Pathophysiology of rheumatoid arthritis

FAH Cooles, JD Isaacs - Current opinion in rheumatology, 2011 - journals.lww.com
Pathophysiology of rheumatoid arthritis : Current Opinion in Rheumatology
Pathophysiology of rheumatoid arthritis : Current Opinion in Rheumatology Log in or …

The pathogenesis of rheumatoid arthritis

S Alivernini, GS Firestein, IB McInnes - Immunity, 2022 - cell.com
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Molecular and cellular pathways contributing to joint damage in rheumatoid arthritis

Q Fang, C Zhou, KS Nandakumar - Mediators of inflammation, 2020 - Wiley Online Library
Rheumatoid arthritis is a chronic autoimmune syndrome associated with several genetic,
epigenetic, and environmental factors affecting the articular joints contributing to cartilage …

Pathogenesis of bone and cartilage destruction in rheumatoid arthritis

SR Goldring - Rheumatology, 2003 - academic.oup.com
Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumour necrosis factor alpha
(TNFα), have been implicated in the dysregulation of bone and cartilage remodelling …

Mechanisms involved in triggering rheumatoid arthritis

AI Catrina, V Joshua, L Klareskog… - Immunological …, 2016 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic inflammatory syndrome with a strong autoimmune
component. The autoantigens in RA are neither tissue nor organ‐specific, but comprise a …