l-Hypaphorine (l-HYP) is an l-tryptophan-derived alkaloid with significant medicinal value.
The objective of this study tried to use Escherichia coli as a chassis cell to produce l-HYP …

Abstract Background 5-hydroxytryptophan (5-HTP), the direct biosynthetic precursor of the
neurotransmitter 5-hydroxytryptamine, has been shown to have unique efficacy in the …

Microbial production of trans‐4‐hydroxy‐l‐proline (Hyp) offers significant advantages over
conventional chemical extraction. However, it is still challenging for industrial production of …

Abstract BACKGROUND Trans‐4‐hydroxy‐L‐proline (Hyp) is a value‐added amino acid
that is an applicable chiral building block in some industries, such as the pharmaceutical …

l-Histidine is an essential proteinogenic amino acid in food with extensive applications in the
pharmaceutical field. Herein, we constructed a Corynebacterium glutamicum recombinant …

Abstract Non-proteinogenic trans-4-hydroxy-l-proline (t4HYP), a crucial naturally occurred
amino acid, is present in most organisms. t4HYP is a regio-and stereo-selectively …

Abstract Trans‐4‐Hydroxy‐l‐proline (trans‐Hyp) is a valuable chiral building block for the
synthesis of pharmaceutical intermediates. Bioconversion of l‐proline using recombinant …

l-Phenylalanine (l-Phe) is widely used in the food and pharmaceutical industries. However,
the biosynthesis of l-Phe using Escherichia coli remains challenging due to its lower …

Background L-phenylalanine is an essential amino acid with various promising applications.
The microbial pathway for L-phenylalanine synthesis from glucose in wild strains involves …

L-methionine is an essential amino acid with versatile applications in food, feed, cosmetics
and pharmaceuticals. At present, the production of L-methionine mainly relies on chemical …