Chondroitin sulfate proteoglycans in the nervous system: inhibitors to repair

JR Siebert, A Conta Steencken… - BioMed research …, 2014 - Wiley Online Library
Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central
nervous system, serving as guidance cues during development and modulating synaptic …

Chondroitin sulfate proteoglycans: Key modulators in the developing and pathologic central nervous system

SM Dyck, S Karimi-Abdolrezaee - Experimental neurology, 2015 - Elsevier
Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

CM Galtrey, JW Fawcett - Brain research reviews, 2007 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan
(GAG) chains. There is enormous structural diversity among CSPGs due to variation in the …

Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity

K Bartus, ND James, KD Bosch, EJ Bradbury - Experimental neurology, 2012 - Elsevier
Chondroitin sulphate proteoglycans (CSPGs) are a family of inhibitory extracellular matrix
molecules that are highly expressed during development, where they are involved in …

Targeting chondroitin sulfate proteoglycans: an emerging therapeutic strategy to treat CNS injury

N Mukherjee, S Nandi, S Garg, S Ghosh… - ACS Chemical …, 2020 - ACS Publications
Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar
formed after severe traumatic brain injury as well as spinal cord injury and play a crucial …

[HTML][HTML] Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation

A Rolls, R Shechter, A London, Y Segev… - PLoS …, 2008 - journals.plos.org
Background Chondroitin sulfate proteoglycan (CSPG) is a major component of the glial scar.
It is considered to be a major obstacle for central nervous system (CNS) recovery after injury …

Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans

TL Laabs, H Wang, Y Katagiri, T McCann… - Journal of …, 2007 - Soc Neuroscience
Chondroitin sulfate proteoglycans (CSPGs) are upregulated in the CNS after injury and
participate in the inhibition of axon regeneration mainly through their glycosaminoglycan …

A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice

A Rolls, H Avidan, L Cahalon, H Schori… - European Journal of …, 2004 - Wiley Online Library
Chondroitin sulphate proteoglycan (CSPG) inhibits axonal regeneration in the central
nervous system (CNS) and its local degradation promotes repair. We postulated that the …

Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate

S Miyata, H Kitagawa - The journal of biochemistry, 2015 - academic.oup.com
Chondroitin sulphate proteoglycans (CSPGs), consisting of core proteins linked to one or
more chondroitin sulphate (CS) chains, are major extracellular matrix (ECM) components of …

Chondroitin sulfate proteoglycans in neural development and regeneration

T Laabs, D Carulli, HM Geller, JW Fawcett - Current opinion in …, 2005 - Elsevier
Proteoglycans are of two main types, chondroitin sulfate (CSPGs) and heparin sulfate
(HSPGs). The CSPGs act mainly as barrier-forming molecules, whereas the HSPGs stabilise …