Chondroitin sulphate proteoglycans (CSPGs) are potent inhibitors of growth in the adult
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …

The extension of axons through the major inhibitory component of the glial scar, chondroitin
sulfate proteoglycans (CSPGs), remains a key obstacle for regeneration following spinal …

Chondroitin sulfate proteoglycan (CSPG), a matrix protein that occurs naturally in the central
nervous system (CNS), is considered to be a major inhibitor of axonal regeneration and is …

Chondroitin sulfate proteoglycans (CSPGs) are upregulated in insults to the central nervous
system, including multiple sclerosis (MS), an inflammatory demyelinating condition of the …

Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that
are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate …

Severed axons in adult mammals do not regenerate appreciably after central nervous
system (CNS) injury due to developmentally determined reductions in neuron-intrinsic …

Background A major class of axon growth-repulsive molecules associated with CNS scar
tissue is the family of chondroitin sulphate proteoglycans (CSPGs). Experimental spinal cord …

Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …

The orderly development of the nervous system is characterized by phases of cell
proliferation and differentiation, neural migration, axonal outgrowth and synapse formation …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …