Chondroitin sulphate proteoglycans (CSPGs) are up‐regulated in the CNS after injury and
inhibit axon regeneration mainly through their glycosaminoglycan (CS‐GAG) chains. We …

The extracellular matrix (ECM) is known to regulate important processes in neuronal cell
development, activity and growth. It is associated with the structural stabilization of neuronal …

Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …

Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found
throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse …

The antiinflammatory and antiapoptotic effects of chondroitin sulfate (CS) are being used to
treat osteoarthritis. Recent evidence has revealed that those peripheral effects of CS may …

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …

After injury to the adult central nervous system (CNS), numerous cytokines and growth
factors are released that contribute to reactive gliosis and extracellular matrix production. In …

Chondroitin sulfate proteoglycans (CSPGs) are the major components of extracellular matrix
in the central nervous system. In the spinal cord under various types of injury, reactive gliosis …

Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration.
However, no specific receptor for the inhibitory effect of CSPGs has been identified. We …

Acute trauma to the central nervous system (CNS) can result in permanent damage and loss
of function related to the poor regeneration of injured axons. Injured axons encounter …