Perisynaptic chondroitin sulfate proteoglycans restrict structural plasticity in an integrin-dependent manner

C Orlando, J Ster, U Gerber, JW Fawcett… - Journal of …, 2012 - Soc Neuroscience
During early postnatal development of the CNS, neuronal networks are configured through
the formation, elimination, and remodeling of dendritic spines, the sites of most excitatory …

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors

D Fisher, B Xing, J Dill, H Li, HH Hoang… - Journal of …, 2011 - Soc Neuroscience
Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules
with various functions in regulating tissue morphogenesis, cell division, and axon guidance …

Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans

H Rauvala, M Paveliev, J Kuja-Panula… - Neural regeneration …, 2017 - journals.lww.com
The current dogma in neural regeneration research implies that chondroitin sulfate
proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous …

The role of extracellular matrix in CNS regeneration

SA Busch, J Silver - Current opinion in neurobiology, 2007 - Elsevier
Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which
form after damage to the adult central nervous system and act as a barrier to regenerating …

Mammalian‐produced chondroitinase AC mitigates axon inhibition by chondroitin sulfate proteoglycans

GM Curinga, DM Snow, C Mashburn… - Journal of …, 2007 - Wiley Online Library
Chondroitin sulfate proteoglycans (CSPGs) are up‐regulated following spinal cord injury
and are partly responsible for failed regeneration. Experimental paradigms in vivo that …

Administration of chondroitinase ABC rostral or caudal to a spinal cord injury site promotes anatomical but not functional plasticity

VJ Tom, R Kadakia, L Santi, JD Houlé - Journal of neurotrauma, 2009 - liebertpub.com
Growth-inhibitory chondroitin sulfate proteoglycans (CSPG) are a primary target for
therapeutic strategies after spinal cord injury because of their contribution to the inhibitory …

Neurite outgrowth inhibition by chondroitin sulfate proteoglycan: stalling/stopping exceeds turning in human neuroblastoma growth cones

DAL Hynds, DM Snow - Experimental neurology, 1999 - Elsevier
Chondroitin sulfate proteoglycan (CSPG) inhibits outgrowth from embryonic chick and
rodent neurons in vivo and in vitro and is upregulated during development and following …

DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage

J Garwood, O Schnädelbach, A Clement… - Journal of …, 1999 - Soc Neuroscience
DSD-1-PG is a chondroitin sulfate proteoglycan (CSPG) expressed by glial cells that can
promote neurite outgrowth from rat embryonic mesencephalic (E14) and hippocampal (E18) …

Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system

N Bukhari, L Torres, JK Robinson… - Journal of …, 2011 - Soc Neuroscience
Spinal cord injury (SCI) causes permanent debilitation due to the inability of axons to grow
through established scars. Both the sugar chains and core proteins of chondroitin sulfate …

Transforming growth factor β-induced expression of chondroitin sulfate proteoglycans is mediated through non-Smad signaling pathways

N Jahan, SS Hannila - Experimental Neurology, 2015 - Elsevier
The expression of chondroitin sulfate proteoglycans (CSPGs) by reactive astrocytes is a
major factor contributing to glial scarring and regenerative failure after spinal cord injury, but …