The repair of myelin, termed remyelination, is a regenerative process that occurs within the
central nervous system in conditions such as multiple sclerosis. Remyelination is enabled by …

Axotomized neurons within the damaged CNS are thought to be prevented from functional
regeneration by inhibitory molecules such as chondroitin sulfate proteoglycans (CSPGs) …

Perineuronal nets (PNNs) are lattice‐like extracellular matrix structures composed of
chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline …

Soluble chondroitin sulfate proteoglycans (CSPGs), prepared from 10-d-old rat brain, were
added to the culture medium of PC12D cells containing NGF to examine the effects on NGF …

Chondroitin sulfate proteoglycans (CSPGs) are upregulated after CNS lesions, where they
inhibit axon regeneration. In order for axon growth and regeneration to occur, surface …

It is well established that axonal regeneration in the adult CNS is largely unsuccessful.
Numerous axon‐inhibitory molecules are now known to be present in the injured CNS, and …

Our past work indicates that growth-inhibiting chondroitin sulfate proteoglycan (CSPG) is
abundant in the peripheral nerve sheaths and interstitium. In this study we tested if …

The inability of neurones to regenerate in the adult mammalian central nervous system
(CNS) is thought to be primarily a consequence of the inhospitable nature of the …

Traumatic injury of the central nervous system is one of the leading causes of death and
disability in young adults. Failure of regeneration is caused by autonomous neuronal …

Serum‐free cultures of meningeal fibroblasts synthesize and release a chondroitin sulphate
proteoglycan (CSPG) that markedly enhances survival but not adhesion of embryonic rat …