Anti-IgE therapy with omalizumab for severe asthma: current concepts and potential developments

G Pelaia, A Vatrella, M Teresa Busceti… - Current Drug …, 2015 - ingentaconnect.com
The humanized monoclonal anti-IgE antibody omalizumab is currently the only biologic drug
approved for asthma treatment. Omalizumab inhibits allergic responses by binding to serum …

[HTML][HTML] Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany

S Korn, A Thielen, S Seyfried, C Taube, O Kornmann… - Respiratory …, 2009 - Elsevier
Omalizumab is a humanized monoclonal anti-immunoglobulin E (IgE) antibody indicated in
Europe for the treatment of uncontrolled severe persistent allergic (IgE-mediated) asthma …

Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study)

RM Niven, D Saralaya, R Chaudhuri, M Masoli… - BMJ open, 2016 - bmjopen.bmj.com
Objective To describe the impact of omalizumab on asthma management in patients treated
as part of normal clinical practice in the UK National Health Service (NHS). Design A non …

Update on optimal use of omalizumab in management of asthma

G Pelaia, L Gallelli, T Renda, P Romeo… - Journal of Asthma …, 2011 - Taylor & Francis
Omalizumab is a humanized monoclonal anti-IgE antibody recently approved for the
treatment of severe allergic asthma. This drug inhibits allergic responses by binding to …

Comparison of extended intervals and dose reduction of omalizumab for asthma control

G Bölke, MK Church, KC Bergmann - Allergo Journal International, 2019 - Springer
Purpose The necessary treatment duration of omalizumab in patients with severe asthma
remains unclear. Currently, common practice is life-long therapy without adjustment of dose …

Novel targets of omalizumab in asthma

C Sattler, G Garcia, M Humbert - Current Opinion in Pulmonary …, 2017 - journals.lww.com
Novel targets of omalizumab in asthma : Current Opinion in Pulmonary Medicine Novel targets
of omalizumab in asthma : Current Opinion in Pulmonary Medicine Log in or Register Subscribe …

Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step …

M Humbert, R Beasley, J Ayres, R Slavin, J Hébert… - Allergy, 2005 - Wiley Online Library
Background: Patients with severe persistent asthma who are inadequately controlled
despite Global Initiative for Asthma (GINA) 2002 step 4 therapy are a challenging population …

Efficacy of omalizumab (Xolair®) in patients with moderate to severe predominately chronic oral steroid dependent asthma in Taiwan: a retrospective, population …

HC Chen, CD Huang, E Chang, HP Kuo - BMC Pulmonary Medicine, 2016 - Springer
Abstract Background Omalizumab (Xolair®), a recombinant monoclonal anti-IgE antibody,
has demonstrated efficacy in clinical trials conducted in patients with moderate to severe …

[HTML][HTML] “Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: the PERSIST study

G Brusselle, A Michils, R Louis, L Dupont… - Respiratory …, 2009 - Elsevier
OBJECTIVE: To evaluate the 16-and 52-week effectiveness of add-on omalizumab
treatment under real-life heterogeneity in patients, settings, and physicians in an open-label …

Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma

ST Holgate, AG Chuchalin, J Hebert… - Clinical & …, 2004 - Wiley Online Library
Background Patients with severe asthma are often inadequately controlled on existing anti‐
asthma therapy, constituting an unmet clinical need. Objective This randomized, double …