BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …

Targeting of the BRAF gene in papillary thyroid carcinoma

Y Li, M Nakamura, K Kakudo - Oncology reports, 2009 - spandidos-publications.com
Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy and
includes several histological variants. Patients suffering from PTC usually have a good …

BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

Clinicopathologic Implications of the BRAFV600E Mutation in Papillary Thyroid Cancer: A Subgroup Analysis of 3130 Cases in a Single Center

JY Lim, SW Hong, YS Lee, BW Kim, CS Park… - Thyroid, 2013 - liebertpub.com
Background: The BRAF mutation has been shown to be associated with aggressive
clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies …

Clinical significance of BRAF (V600E) mutation and Ki-67 labeling index in papillary thyroid carcinomas

H Nakayama, A Yoshida, Y Nakamura… - Anticancer …, 2007 - ar.iiarjournals.org
Background: Activating mutations of the BRAF gene have recently been reported in thyroid
carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma …

Clinical Significance of BRAF Mutation in Thyroid Papillary Cancer

IJ Fernandez, O Piccin, S Sciascia… - … –Head and Neck …, 2013 - journals.sagepub.com
Objective To correlate the presence of BRAF V600E mutation with clinicopathological
parameters. Study Design Case-control study. Setting BRAF mutation represents the most …

Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma

C Lupi, R Giannini, C Ugolini, A Proietti… - The Journal of …, 2007 - academic.oup.com
Context: Because very few studies have examined the correlation between BRAF mutations
and clinicopathological features of papillary thyroid carcinoma (PTC), we analyzed here a …

Clinical impact of the detection of BRAF mutations in thyroid pathology: potential usefulness as diagnostic, prognostic and theragnostic applications

S Lassalle, V Hofman, M Ilie, C Butori… - Current medicinal …, 2010 - ingentaconnect.com
A BRAF somatic mutation at residue 600 of the BRAF protein (BRAFV600E) is highly
prevalent in papillary thyroid carcinomas (PTC). This mutation occurs in approximately …

Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: A meta‐analysis

JH Lee, ES Lee, YS Kim - Cancer, 2007 - Wiley Online Library
BACKGROUND. Numerous studies have investigated the clinical significance of BRAF
mutation in papillary thyroid carcinoma (PTC). However, there have been conflicting data on …

BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer

M Xing, WH Westra, RP Tufano, Y Cohen… - The Journal of …, 2005 - academic.oup.com
Context: Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve
risk stratification of this cancer. Objective: The objective of the study was to investigate the …