Amiodarone, an antiarrhythmic and anti-anginal agent, contains 75mg oforganic iodine per
200mg active substance. The drug is deiodinated during its biotransformation, and it is …

An antiarrhythmic drug, amiodarone, contains 37% iodine by weight and is structurally
similar to the thyroid hormones. The drug inhibits hepatic 5'-deiodinase, resulting in …

Amiodarone, an iodinated benzofuran derivative, was introduced in the 1960s as an
antianginal agent with coronary vasodilator properties. Later description of its antiaiThythmic …

Both hyperthyroidism and hypothyroidism have been noted to occur in some patients treated
with amiodarone for cardiac arrhythmias. To determine the frequency of the development of …

Amiodarone is a potent antiarrhythmic drug associated with thyroid dysfunction. Its high
iodine content causes inhibition of 5'-deiodinase activity. Most patients remain euthyroid …

Thyroid function was evaluated clinically and biochemically in 12 patients with ischaemic
heart disease receiving 200 mg oral amiodarone three times daily for periods up to 6 weeks …

Iodine kinetic studies were performed serially in 15 patients taking 300 mg amiodarone/day
for 6 months to assess the biological significance of the high iodine content of the drug …

Amiodarone has been reported as an anti-anginal drug in 19h7 [11 and as an anti-
arrhythmic drug in 1969 [2]. Thyroid side-effects (hypothyroidism and thyrotoxicosis) were …

Amiodarone, an iodinated benzofuran derivative, is used for treatment of refractory cardiac
arrhythmias. Certain features of the drug's structure resemble those of the biologically active …

Amiodarone, a benzofuranic-derivative iodine-rich drug used mostly for tachyarrhythmias,
often causes changes in the peripheral metabolism of thyroid hormones mainly due to the …