Tumor progression is strongly associated with the activity of receptor tyrosine kinases
(RTKs) and their intracellular signal transduction pathways, which regulate several cell …

Tyrosine phosphorylation has a key role in intracellular signaling. Inappropriate proliferation
and survival cues in tumor cells often occur as a consequence of unregulated tyrosine …

Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …

Abstract c-Kit is a type III receptor tyrosine kinase (RTK) that has an essential role in various
biological functions including gametogenesis, melanogenesis, hematopoiesis, cell survival …

Receptor tyrosine kinases play an important role in many cellular processes, and their
dysregulation leads to diseases, most importantly cancer. One such receptor tyrosine kinase …

Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling
receptor for a number of cell types, including hematopoietic stem cells, mast cells …

Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce
signals from the environment into the cell leading to complex behaviors such as …

As an important member of tyrosine kinase family, c-kit receptor causes specific expression
of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and …

The c-Kit proto-oncogene is a receptor protein-tyrosine kinase associated with several
highly malignant human cancers. Upon binding its ligand, stem cell factor (SCF), c-Kit forms …

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …