Release of properly processed and assembled mRNPs from the actively transcribing genes,
movement of the mRNPs through the interchromatin and interaction with the Nuclear Pore …

Regulation of gene expression can occur at many different levels. One important step in the
gene expression process is the transport of mRNA from the nucleus to the cytoplasm. In …

Cellular mRNAs are produced in the nucleus and must be exported to the cytoplasm to allow
for their translation into proteins. Recruitment of export factors to nascent mRNA starts …

mRNAs are transported from the nucleus to the cytoplasm by a machinery conserved from
yeast to humans. Previous studies showed that mRNA export factors are loaded on nascent …

Transcription is a central function occurring in the nucleus of eukaryotic cells in coordination
with other nuclear processes. During transcription, the nascent pre-mRNA associates with …

Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well
coordinated processing steps, resulting in the formation of an export competent …

Expression of protein-coding genes in eukaryotes relies on the coordinated action of many
sophisticated molecular machineries. Transcription produces precursor mRNAs (pre …

The cell nucleus is an intricate organelle that coordinates multiple activities that are
associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic …

The nuclear export of mRNA, in which Mex67–Mtr2 mediates movement of mature
transcripts through nuclear pores, represents the culmination of the nuclear portion of the …

Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is
central for physiological responses to extracellular and intracellular signals. An essential …