Cancer stem cells niche: a target for novel cancer therapeutics

SY Yi, YB Hao, KJ Nan, TL Fan - Cancer treatment reviews, 2013 - Elsevier
Nowadays, cancer has been a frequent disease, and the first or second most common cause
of death worldwide. Despite a better understanding of the biology of cancer cells, the …

The clinical and therapeutic implications of cancer stem cell biology

L Cheng, R Alexander, S Zhang, CX Pan… - Expert Review of …, 2011 - Taylor & Francis
Cancer stem cells (CSCs) have provided new insights into the tumorigenesis and metastatic
potential of cancer. The discovery of CSCs has provided many new insights into the …

[HTML][HTML] Advances in therapeutic targeting of cancer stem cells within the tumor microenvironment: an updated review

K Dzobo, DA Senthebane, C Ganz, NE Thomford… - Cells, 2020 - mdpi.com
Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment

J Ye, D Wu, P Wu, Z Chen, J Huang - Tumor Biology, 2014 - Springer
Despite recent progresses in tumor therapy and increased knowledge in tumor biology,
tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a …

Cancer stem cells and therapeutic targets: an emerging field for cancer treatment

AP Vaz, MP Ponnusamy, SK Batra - Drug delivery and translational …, 2013 - Springer
Recent paradigm in the field of cancer defines its origin from a small population of fast-
growing cells known as cancer stem cells (CSCs), and they are mainly responsible for …

[HTML][HTML] Characteristics of the cancer stem cell niche and therapeutic strategies

F Ju, MM Atyah, N Horstmann, S Gul, R Vago… - Stem Cell Research & …, 2022 - Springer
Distinct regions harboring cancer stem cells (CSCs) have been identified within the
microenvironment of various tumors, and as in the case of their healthy counterparts, these …

[HTML][HTML] Therapeutic strategies targeting cancer stem cells and their microenvironment

HR Sun, S Wang, SC Yan, Y Zhang, PJ Nelson… - Frontiers in …, 2019 - frontiersin.org
Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to
act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of …

Cancer stem cells: powerful targets to improve current anticancer therapeutics

RL Bighetti-Trevisan, LO Sousa… - Stem cells …, 2019 - Wiley Online Library
A frequent observation in several malignancies is the development of resistance to therapy
that results in frequent tumor relapse and metastasis. Much of the tumor resistance …

Cancer stem cells: acquisition, characteristics, therapeutic implications, targeting strategies and future prospects

AK Yadav, NS Desai - Stem Cell Reviews and Reports, 2019 - Springer
Since last two decades, the major cancer research has focused on understanding the
characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to …

Cancer stem cell niche: the place to be

T Borovski, F De Sousa E Melo, L Vermeulen… - Cancer research, 2011 - AACR
Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …