The self-assembly of the amyloid beta (Aβ) peptides into senile plaques is the hallmark of
Alzheimer's disease. Recent experiments have shown that the English familial disease …

The aggregation of amyloid beta (Aβ) peptides plays an important role in the development of
Alzheimer's disease. Despite extensive effort, it has been difficult to characterize the …

Although the Aβ37–42 peptide has two opposite terminal charges, counterintuitively its
current fibril amyloid structure reveals in register parallel β-strands, as formed by the full …

Alzheimer's disease is a neurodegenerative disorder characterized by progressive
deposition of amyloid-beta (Aβ) peptides in brain parenchyma and cerebral blood vessels …

The oligomerization of amyloid beta (Aβ) peptides into soluble non-fibrillar species plays a
critical role in the pathogenesis of Alzheimer's disease. However, it has been challenging to …

Accumulation of the amyloid beta (Aβ) peptide in the brain is responsible for debilitating
neurodegenerative diseases, such as Alzheimer's disease (AD). We have carried out …

Alzheimer's disease is associated with the abnormal self-assembly of amyloid-β (Aβ)
peptide into toxic oligomers and fibrils. Recent experiments reported that Aβ16− 22 …

Amyloid beta (Aβ) oligomerization is associated with the origin and progression of
Alzheimer's disease (AD). While the A2V mutation enhances aggregation kinetics and …

The self-assembly of the amyloid-β (Aβ) peptide of 39–43 amino acids into senile plaques is
one hallmark of Alzheimer's disease (AD) pathology. While A2 V carriers remain healthy in …

Single amino acid mutations in amyloid-beta (Aβ) peptides can lead to early onset and
increased severity of Alzheimer's disease. An example is the Osaka mutation (Aβ1 …