Background The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+
dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to …

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been implicated in the etiology
of various human malignant tumors; however, its exact role in bladder cancer (BC) remains …

Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino
acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts …

Although combination chemotherapy is widely used for bladder cancer (BC) treatment, the
recurrence and progression rates remain high. Therefore, novel therapeutic targets are …

Background: Defects in methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L)
expression have earlier been examined in only a few human cancers. Objectives: Multi …

Background/Aims: To investigate the role of methylenetetrahydrofolate dehydrogenase 2
(MTHFD2) in the clinical prognosis and cell biology of renal cell carcinoma (RCC). Methods …

Liver hepatocellular carcinoma (LIHC) is one of the most frequently occurring primary
malignant liver tumors and seriously harms people's health in the world …

Background NAD-dependent methylenetetrahydrofolate dehydrogenase catalyzes the
conversion of 10-formyltetrahydrofolate to formate in embryonic and adult mammalian …

Purpose Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a tetramethylfolate
dehydrogenase enzyme involved in folate metabolism. The aim of this study is to determine …

Abstract Background Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is the key
enzyme in the transformation of folic acid metabolites. MTHFD2 overexpression plays a key …