FOXO transcription factors in cell-cycle regulation and the response to oxidative stress

Y Furukawa-Hibi, Y Kobayashi, C Chen… - Antioxidants & redox …, 2005 - liebertpub.com
Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1,
FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes …

The extending network of FOXO transcriptional target genes

KE van der Vos, PJ Coffer - Antioxidants & redox signaling, 2011 - liebertpub.com
The evolutionarily conserved Forkhead box O (FOXO) family of transcription factors
regulates multiple transcriptional targets involved in various cellular processes, including …

The foxo code

DR Calnan, A Brunet - Oncogene, 2008 - nature.com
Abstract The FoxO family of Forkhead transcription factors plays an important role in
longevity and tumor suppression by upregulating target genes involved in stress resistance …

Post-translational regulation of FOXO

Q Xie, J Chen, Z Yuan - Acta Biochim Biophys Sin, 2012 - academic.oup.com
Abstract The Forkhead box O (FOXO) family transcription factors play critical roles in a series
of cellular processes, including the cell cycle, cell death, metabolism, and oxidative stress …

Forkhead homeobox type O transcription factors in the responses to oxidative stress

P Storz - Antioxidants & redox signaling, 2011 - liebertpub.com
Reactive oxygen species (ROS) and cellular oxidative stress are involved in many
physiological and pathophysiological processes, including cellular and organismal aging …

FOXO transcription factors: key regulators of cell fate

EWF Lam, RE Francis, M Petkovic - 2006 - portlandpress.com
FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of
FOXO proteins relies on their ability to control diverse and at times, opposing cellular …

Stressing the role of FoxO proteins in lifespan and disease

A van der Horst, BMT Burgering - Nature reviews Molecular cell biology, 2007 - nature.com
Members of the class O of forkhead box transcription factors (FoxO) have important roles in
metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of …

Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer

KC Arden - Experimental gerontology, 2006 - Elsevier
The FOXO family of transcription factors has been implicated in several cellular processes
including cell cycle arrest, cell death and protection from stress stimuli. FOXO function is …

FOXO1: a potential target for human diseases

H Lu, H Huang - Current drug targets, 2011 - ingentaconnect.com
The forkhead box O (FoxO) transcription factors are known to be involved in many
physiological and pathological processes including apoptosis, cell cycle arrest, stress …

FoxO transcription factors in oxidative stress response and ageing–a new fork on the way to longevity?

DG Sedding - 2008 - degruyter.com
Forkhead box O (FoxO) transcription factors are important downstream targets of the
PI3K/Akt signaling pathway and crucial regulators of cell fate. This function of FoxOs relies …