Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

Background The prognosis of pancreatic cancer remains desperately poor, with little
progress made over the past 30 years despite the development of new combination …

The abundant stromal/desmoplastic reaction, a characteristic feature of a majority of
pancreatic adenocarcinomas (PDAC), has only recently been receiving some attention …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now
known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …

Pancreatic stellate cells are stromal cells that have multiple physiological functions such as
the production of extracellular matrix, stimulation of amylase secretion, phagocytosis and …

One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …