New treatments are needed to protect the myocardium against the detrimental effects of
acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in …

Mitochondria are dynamic in nature and are able to shift their morphology between
elongated interconnected mitochondrial networks and a fragmented disconnected …

Mitochondrial fusion and fission are essential for heart function. Abrogating mitochondrial
dynamism leads to cardiomyopathy. Excessive mitochondrial fragmentation is involved in …

Pathological cardiac hypertrophy begins as an adaptive response to increased workload;
however, sustained hemodynamic stress will lead it to maladaptation and eventually cardiac …

Mitochondrial fission is a crucial process in maintaining metabolic homeostasis in normal
physiology and under conditions of stress. Its dysregulation has been associated with …

Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such novel therapies are needed to …

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and
fusion events, forming networks. These dynamic events allow the transmission of chemical …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial
function and quality control. Mitochondrial fusion and division are integrated into diverse …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …