Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Mitochondria are dynamic organelles that can undergo fusion, fission, biogenesis, and
autophagic elimination to maintain mitochondrial quality control. Since the heart is in …

Mitochondria contribute to cardiac dysfunction and myocyte injury via a loss of metabolic
capacity and by the production and release of toxic products. This article discusses aspects …

The contribution that mitochondria make to cardiac function extends well beyond their critical
bioenergetic role as a supplier of ATP. The organelle plays an integral part in the regulatory …

The ATP consumption in heart is very intensive to support muscle contraction and relaxation.
Mitochondrion is the power plant of the cell. Mitochondrial dysfunction has long been …

Mitochondria are essential organelles that generate energy to fuel myocardial contraction.
Accumulating evidence also suggests that, in the heart, mitochondria may contribute to …

Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …

Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy
population of mitochondria and cellular homeostasis. Coordinated interplay between these …

The mitochondria form dynamic organized networks or filaments that are controlled by fusion
and fission events. A balance between mitochondrial fusion and fission is crucial for the …

Recent advancement in mitochondrial research has significantly extended our knowledge
on the role and regulation of mitochondria in health and disease. One important …