Modulation of angiogenesis is a promising approach for treating a wide variety of human
diseases including ischemic heart disease and cancer. In this study, we show that ADAM-17 …

Mesangial cells (MC) occupy the core of the renal glomerulus and are surrounded by a
mesangial matrix. In certain diseases, MC migrate through this matrix into the pericapillary …

The disintegrin metalloproteases (or ADAMs) are membrane-anchored glycoproteins that
have been implicated in cell-cell or cell-matrix interactions and in proteolysis of molecules …

By mediating proteolytic shedding on the cell surface the disintegrin and metalloproteinases
ADAM10 and ADAM17 function as critical regulators of growth factors, cytokines and …

ADAM17, a disintegrin and metalloproteinase 17, is a transmembrane metalloproteinase
that regulates bioavailability of multiple membrane-bound proteins via ectodomain …

Abstract “A disintegrin and metalloproteinases”(ADAMs) form a family of cell‐surface
glycoproteins with potential protease and cell‐adhesion activities. We have investigated …

ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney
disease (DKD) is unclear. Diabetic Timp3−/− mice showed increased albuminuria …

ADAM15 is a member of the family of metalloprotease-disintegrins that have been shown to
interact with integrins in an RGD-and non-RGD-dependent manner. In the present study, we …

A disintegrin and metalloproteinase domain 10 (Adam10), a member of the ADAM family of
cell membrane–anchored proteins, has been linked to the regulation of the Notch, EGF, E …

Recent data show that increases in bradykinin (BK) concentration contribute to the beneficial
effects of angiotensin-converting enzyme inhibitor (ACEI) treatment in chronic kidney …