Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains

YP Sun, KJ Deng, F Wang, J Zhang, X Huang, S Qiao… - Gene, 2004 - Elsevier
A metalloprotease and disintegrin (ADAM) is a family of membrane-anchored proteins and
all family members have a multi-domain structure containing a zinc metalloprotease domain …

Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins

I Kleino, RM Ortiz, M Yritys… - Journal of cellular …, 2009 - Wiley Online Library
Abstract A Disintegrin And Metalloprotease (ADAM15) is a member of the adamalysin
protein family and has been associated with cancer, possibly via its role in ectodomain …

Targeting ADAM12 in human disease: head, body or tail?

J Jacobsen, UM Wewer - Current pharmaceutical design, 2009 - ingentaconnect.com
ADAM12/meltrin α is a type I transmembrane multidomain protein involved in tumor
progression and other severe diseases, including osteoarthritis, and as such could be …

[HTML][HTML] Renal ADAM10 and 17: their physiological and medical meanings

T Kato, M Hagiyama, A Ito - Frontiers in cell and developmental …, 2018 - frontiersin.org
A disintegrin and metalloproteinases (ADAMs) are a Zn2+-dependent transmembrane and
secreted metalloprotease superfamily, so-called “molecular scissors,” and they consist of an …

ADAM12: a genetic modifier of preclinical peripheral arterial disease

AO Dokun, L Chen, M Okutsu… - American Journal …, 2015 - journals.physiology.org
In prior studies from multiple groups, outcomes following experimental peripheral arterial
disease (PAD) differed considerably across inbred mouse strains. Similarly, in humans with …

Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice

KB Pedersen, H Chodavarapu, C Porretta… - …, 2015 - academic.oup.com
Angiotensin-converting enzyme 2 (ACE2) gene therapy aimed at counteracting pancreatic
ACE2 depletion improves glucose regulation in two diabetic mouse models: db/db mice and …

ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3

S Mochizuki, M Shimoda, T Shiomi, Y Fujii… - … and biophysical research …, 2004 - Elsevier
ADAM28, a member of a disintegrin and metalloproteinase (ADAM) family, has two isoforms,
membrane-type form (ADAM28m) and secreted form (ADAM28s). Although ADAM28 is …

ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices

H Kwak, EA Mendoza, KJ Bayless - Matrix Biology, 2009 - Elsevier
In this study, we investigated potential mechanisms through which the known anti-
angiogenic factor, tissue inhibitor of metalloproteinase-3 (TIMP-3) blocks angiogenesis. As a …

ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis

JW Holloway, RC Laxton, MJ Rose-Zerilli, JA Holloway… - Atherosclerosis, 2010 - Elsevier
A-disintegrin-and-metalloproteinase-domains (ADAMs) are membrane-anchored
glycoproteins involved in cell adhesion, cell migration and proteolysis. ADAM15 has been …

[HTML][HTML] Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice

F Xue, J Cheng, Y Liu, C Cheng, M Zhang… - … and Targeted Therapy, 2022 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …